ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias.
Jun He, Brenda Cabrera-Mendoza, Eleni Friligkou, Adam P Mecca, Christopher H van Dyck, Gita A Pathak, Renato Polimanti
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Jun HeDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Brenda Cabrera-MendozaDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Eleni FriligkouDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Adam P MeccaDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Christopher H van DyckDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Gita A PathakDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Renato PolimantiDepartment of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.
Funding
Technology to Empower Changes in Health (TECH) Network Participant Technologies CenterU24OD023176 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2016 to 2022
$204.7M
Precision Medicine Initiative Cohort Program BiobankU24OD023121 · OD · MAYO CLINIC ROCHESTER · PI CEKANOVA, MARIA, CICEK, MINE · 2016 to 2024
$185.5M
Enhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research CenterU2COD023196 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, DAVID, HARRIS, PAUL A. · 2016 to 2022
$143.7M
Adaptive Platform for Personalized EngagementU24OD023163 · OD · VIGNET, INC. · PI JAIN, PRADUMAN · 2017 to 2020
$102.6M
University of Arizona-Banner Health All of Us Research Program OT2OD026549 · OD · UNIVERSITY OF ARIZONA · PI MORENO, FRANCISCO A, REIMAN, ERIC MICHAEL · 2018 to 2023
$78.9M
California Precision Medicine Research Program ConsortiumOT2OD026552 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANTON-CULVER, HODA A, OHNO-MACHADO, LUCILA · 2018 to 2023
$73.4M
All of Us PennsylvaniaOT2OD026554 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E, VISWESWARAN, SHYAM · 2018 to 2023
$72.1M
New York City Consortium for Precision MedicineOT2OD026556 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BIER, LOUISE E, GHARAVI, ALI G · 2018 to 2023
$67.3M
SouthEast Enrollment Center (SEEC) OT2OD026551 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, COLON, VIVIAN · 2018 to 2023
$62.8M
Southern All of Us NetworkOT2OD026548 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N., KORF, BRUCE R · 2018 to 2023
$60.5M
Illinois Precision Medicine Consortium OT2OD026557 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AHSAN, HABIBUL, ARGOS, MARIA · 2018 to 2023
$60.5M
The New England Precision Medicine Consortium of the All of Us Research ProgramOT2OD026553 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CLARK, CHERYL RENEE, KARLSON, ELIZABETH W · 2018 to 2023
$58.8M
Alzheimer's Association Research Fellowship AARF-22-967171American Foundation for Suicide Prevention PDF-0-065-23American Foundation for Suicide Prevention PDF-1-022-21Biobank 1 U24 OD023121Communications and Engagement 3 OT2 OD023205Communications and Engagement 3 OT2 OD023206Community Partners 1 OT2OD025276Community Partners 1 OT2 OD025277Community Partners 1 OT2 OD025337Community Partners 3 OT2 OD025315Data and Research Center 5 U2C OD023196Federally Qualified Health Centers HHSN 263201600085UNIA NIH HHS K99 AG078503NIDA NIH HHS R33 DA047527NIH HHS 5K99AG078503-02NIH HHS OT2 OD023205NIH HHS OT2 OD023206NIH HHS OT2 OD025276NIH HHS OT2 OD025277NIH HHS OT2 OD025315NIH HHS OT2 OD025337NIH HHS OT2 OD026548NIH HHS OT2 OD026549NIH HHS OT2 OD026550NIH HHS OT2 OD026551NIH HHS OT2 OD026552NIH HHS OT2 OD026553NIH HHS OT2 OD026554NIH HHS OT2 OD026555NIH HHS OT2 OD026556NIH HHS OT2 OD026557NIH HHS R33 DA047527NIH HHS RF1 MH132337NIH HHS U24 OD023121NIH HHS U24 OD023163NIH HHS U24 OD023176NIH HHS U2C OD023196NIMH NIH HHS RF1 MH132337ODCDC CDC HHS U24 OD023176Office of the Director: Regional Medical Centers 1 OT2 OD026548Office of the Director: Regional Medical Centers 1 OT2 OD026549Office of the Director: Regional Medical Centers 1 OT2 OD026550Office of the Director: Regional Medical Centers 1 OT2 OD026551Office of the Director: Regional Medical Centers 1 OT2 OD 026552Office of the Director: Regional Medical Centers 1 OT2 OD026553Office of the Director: Regional Medical Centers 1 OT2 OD026554Office of the Director: Regional Medical Centers 1 OT2 OD026555Office of the Director: Regional Medical Centers 1 OT2 OD026556Office of the Director: Regional Medical Centers 1 OT2 OD026557Office of the Director: Regional Medical Centers IAA #: AOD 16037Participant Technology Systems Center 1 U24 OD023163Yale Franke Program in Science and Humanities
6 · The paper itself
Abstract
introductionLimited information is available regarding sex differences in the relationship of socioeconomic status and cognitive performance with Alzheimer's disease and related dementias (ADRD) family history.
methodsLeveraging the UK Biobank (N = 448,100) and All of Us Research Program (N = 240,319), we conducted observational and genetically informed analyses to test the sex-specific associations of socioeconomic factors and cognitive performance with ADRD and its family history.
resultsObservational and genetically informed analyses highlighted that higher socioeconomic status and cognitive performance were associated with reduced ADRD and sibling-ADRD family history. Conversely, these were associated with increased parent-ADRD family history. Sex differences in these relationships were also identified. Additionally, although their sample size was limited, population minorities showed different patterns with respect to ADRD versus parent-ADRD family history. DISCUSSION: This study highlights sex differences in the misestimated associations of ADRD family history that appear to be related to socioeconomic factors and cognitive performance. HIGHLIGHTS: Alzheimer's disease family history is differently linked to socioeconomic factors. Observational and genetic analyses highlighted sex differences in these dynamics. Cause-effect relationships could contribute to biases in Alzheimer's disease assessment.
Indexed as
Alzheimer DiseaseCognitionDementiaSex CharacteristicsSocial ClassSocioeconomic FactorsAgedFemaleHumansMaleMiddle AgedSex FactorsUnited KingdomAlzheimer's disease and related dementiascognitive performancefamily historyMendelian randomizationpolygenic risk scoressocioeconomic factors
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Sex differences in the confounders influencing the relationships linking socioeconomic factors and cognitive performance with family history of Alzheimer's disease and related dementias. · full record | OpenQuestion