Evidence map›Paper›PMID 40421717›Full record

ArticleArtificial organs2025

The Role of Scalp EEG Recordings During Cortical Visual Prosthesis Testing.

Katarina Stephan, Philip R Troyk, Gislin Dagnelie, Stuart Cogan, Michael P Barry, Patricia Grant, Frank Lane, Janet P Szlyk, Maggie McNulty, Wim van Drongelen and 4 more

Registry-linked trialAbstract readClinical Trial, Phase I
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04634383 (ICVP - A Phase I Clinical Trial to Determine the Feasibility of a Human Cortical Visual Prosthesis for People With Blindness), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04634383 narecruitingnot on this map

ICVP - A Phase I Clinical Trial to Determine the Feasibility of a Human Cortical Visual Prosthesis for People With Blindness

TypeinterventionalSponsorIllinois Institute of TechnologyRan2020 to 2027Enrolled5ConditionsOcular Injury, Optic Nerve Diseases, Photoreceptor Degeneration, Blindness,AcquiredArmsWFMA - wireless floating microelectrode array
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Chronic alteration of CaBiomaterials · 2026
    Article
  2. Review
  3. Chronic alteration of CabioRxiv : the preprint server for biology · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Katarina StephanStritch School of Medicine, Loyola University Chicago, Maywood, Illinois, USA.
Philip R TroykPritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.
Gislin DagnelieWilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.
Stuart CoganDepartment of Bioengineering, The University of Texas at Dallas, Richardson, Texas, USA.
Michael P BarryPritzker Institute of Biomedical Science and Engineering, Illinois Institute of Technology, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-0566-2383
Patricia GrantThe Chicago Lighthouse, Chicago, Illinois, USA.
Frank LaneDepartment of Psychology, Illinois Institute of Technology, Chicago, Illinois, USA.
Janet P SzlykThe Chicago Lighthouse, Chicago, Illinois, USA.
Maggie McNultyDepartment of Neurology, Rush University Medical Center, Chicago, Illinois, USA.
Wim van DrongelenDepartment of Pediatrics, The University of Chicago, Chicago, Illinois, USA.
Tuan H PhamDepartment of Neuroscience, Brown University, Providence, Rhode Island, USA.
Kelsey L StippThe Chicago Lighthouse, Chicago, Illinois, USA.
Meesa RoysterThe Chicago Lighthouse, Chicago, Illinois, USA.
Vernon L TowleDepartment of Neurology, The University of Chicago, Chicago, Illinois, USA.ORCID https://orcid.org/0009-0003-7202-6058

Funding

Clinical Testing of an Intracortical Visual Prosthesis SystemUH3NS095557 · NINDS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI Philip R Troyk · 2020 to 2026
$6.1M
Clinical Testing of an Intracortical Visual Prosthesis SystemUG3NS095557 · NINDS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI TROYK, PHILIP R · 2016 to 2018
$5.2M
Intracortical Visual ProthesisR01EB002184 · NIBIB · ILLINOIS INSTITUTE OF TECHNOLOGY · PI TROYK, PHILIP R. · 2003 to 2005
$2.6M
Lions InternationalNIBIB NIH HHS R01 EB002184NIH HHSNINDS NIH HHS UG3 NS095557NINDS NIH HHS UH3 NS095557The Chicago Lighthouse
6 · The paper itself

Abstract

introductionThis article highlights the value of recording scalp electroencephalogram (EEG) from two individuals with blindness who received intracortical visual stimulators to create artificial vision. Given the known risk of cortical stimulation inducing seizures, we recorded occipital scalp EEG as a safety precaution. Over a 3-year period, over 330 h of EEG data were collected.

methodsTwenty-five wireless floating microelectrode arrays (WFMAs), each containing 16 stimulating electrodes, were implanted in the right dorsolateral occipital cortex of the first participant, totaling 400 independently controlled stimulating electrodes. Similarly, 32 WFMAs were implanted in the second participant's cortex, totaling 512 electrodes. Phosphenes were characterized and mapped to align their locations in the visual field to create camera-driven imagery of the visual environment.

resultsScalp EEG recordings during intracortical stimulation provided early warning of impending epileptic activity, reducing the risk of stimulation-induced seizures. In two instances, seizures occurred during direct cortical stimulation and were visible in the scalp EEG recordings. Normal electrically evoked potentials (eEPs) were also evident in the EEG records.

conclusionScalp EEG can be valuable to alert researchers to impending seizures. However, it is not required for conditions in which low levels of stimulation are employed.

trial registrationClinical Trial Number NCT04634383.

Indexed as

BlindnessElectroencephalographySeizuresVisual CortexVisual ProsthesisAgedElectrodes, ImplantedEvoked Potentials, VisualHumansMaleMicroelectrodesMiddle AgedScalpSingle-Case Studies as Topicdirect stimulation of human visual cortexintracortical human visual prosthesisminimizing the risk of seizures during direct intracortical stimulationphosphenes from direct cortical stimulationscalp EEG recordings during intracortical prosthesis testingvisual prosthesis

Identifiers

PMID40421717
PMCPMC12270251

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.