Evidence map›Paper›PMID 40421691›Full record

ArticleImmunology2025

Delineation of the Human Germinal Centre Immune Landscape Using Multiplex Imaging Analysis.

Spiros Georgakis, Michail Orfanakis, Craig Fenwick, Cloe Brenna, Simon Burgermeister, Helen Lindsay, Giuliana Xavier de Medeiros, Fernanda Romano Bruno, Susan Pereira Ribeiro, Raphael Gottardo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Spiros GeorgakisDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.ORCID 0000-0002-9398-3143
Michail OrfanakisDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Craig FenwickService of Immunology and Allergy, Department of Medicine, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Cloe BrennaDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Simon BurgermeisterDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Helen LindsayBiomedical Data Science Center, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Giuliana Xavier de MedeirosPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Fernanda Romano BrunoPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Susan Pereira RibeiroPathology Advanced Translational Research Unit (PATRU), Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Raphael GottardoBiomedical Data Science Center, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Giuseppe PantaleoService of Immunology and Allergy, Department of Medicine, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.
Constantinos PetrovasDepartment of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and Lausanne University, Lausanne, Switzerland.

Funding

Reversing Immune Dysfunction for HIV-1 EradicationUM1AI164561 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI SUMIT K CHANDA, Paula M Cannon · 2021 to 2026
$30.0M
National Institutes of Health, NIAID 7UM AI164561NIAID NIH HHS UM1 AI164561Swiss National Science Foundation 310030_204226
6 · The paper itself

Abstract

Given the role of follicular immune dynamics, especially the germinal centre, for the development of pathogen-specific antibodies, their in situ characterisation is of great importance. We have developed a multiplex immunofluorescence imaging pipeline that allows the analysis of human follicular adaptive and innate immune cell subsets. Our data revealed the in situ phenotypic heterogeneity and differential localisation of follicular helper CD4 T (T

Indexed as

Germinal CenterLymph NodesPalatine TonsilT Follicular Helper CellsFemaleFluorescent Antibody TechniqueHumansImmunity, InnateMalefolliclesimmune landscapingmultiplex imagingTFH cells

Identifiers

PMID40421691
PMCPMC12318895

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.