Evidence map›Paper›PMID 40421622›Full record

ArticleThe international journal of medical robotics + computer assisted surgery : MRCAS2025

Retroperitoneal Versus Transperitoneal Robot Assisted Partial Nephrectomy: A Prospective Controlled Non-Randomized Single Centre Study Non-Inferiority Design.

Rene Mager, Igor Tsaur, Thomas Höfner, Mohamed Kamal Gheith, Gregor Duwe, Maximilian Haack, Jonathan Azar, Brahim Aboulmaouahib, Stefanie Ziewers, Peter Sparwasser and 3 more

Abstract readComparative Study
In one paragraph

Article in The international journal of medical robotics + computer assisted surgery : MRCAS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rene MagerDepartment of Urology and Paediatric Urology, University Medical Center Mainz, Mainz, Germany.ORCID https://orcid.org/0000-0003-1286-0502
Igor TsaurDepartment of Urology and Paediatric Urology, University Medical Center Mainz, Mainz, Germany.
Thomas HöfnerDepartment of Urology and Paediatric Urology, University Medical Center Mainz, Mainz, Germany.
Mohamed Kamal GheithDepartment of Urology and Paediatric Urology, University Medical Center Mainz, Mainz, Germany.
Gregor DuweDepartment of Urology and Paediatric Urology, University Medical Center Mainz, Mainz, Germany.
Maximilian HaackDepartment of Urology and Paediatric Urology, University Medical Center Mainz, Mainz, Germany.
Jonathan AzarDepartment of Urology and Paediatric Urology, University Medical Center Mainz, Mainz, Germany.
Brahim AboulmaouahibInstitute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center Mainz, Mainz, Germany.
Stefanie ZiewersDepartment of Urology and Paediatric Urology, University Medical Center Mainz, Mainz, Germany.
Peter SparwasserDepartment of Urology and Paediatric Urology, University Medical Center Mainz, Mainz, Germany.
Lisa FreyDepartment of Urology and Paediatric Urology, University Medical Center Mainz, Mainz, Germany.
Anita ThomasDepartment of Urology and Paediatric Urology, University Medical Center Mainz, Mainz, Germany.
Axel HaferkampDepartment of Urology and Paediatric Urology, University Medical Center Mainz, Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe value of the retroperitoneal (R-RAPN) compared with the conventional transperitoneal (T-RAPN) approach in robot-assisted partial nephrectomy has not been finally clarified. The current work's objective was to prospectively investigate R-RAPN versus T-RAPN.

methodsThe study was designed as a prospective, controlled, non-randomized study with a non-inferiority design. The primary endpoint was Trifecta achievement. The sample size calculation required 141 T-RAPN and 94 R-RAPN.

resultsWhen the recruitment target of 141 was reached in the T-RAPN arm, only 34 R-RAPN had been performed, so the study was terminated early. Trifecta as the main outcome parameter was achieved in 82% of the R-RAPN and 76% of the T-RAPN groups, so no sign for inferiority could be detected (p = 0.6).

conclusionsIn this prospective study, there was no evidence of inferiority of R-RAPN compared to T-RAPN for the Trifecta endpoint. R-RAPN may be an individually advantageous alternative to T-RAPN for selected patients.

trial registrationThe study was registered in the German Clinical Trials Register (DRKS00028619).

Indexed as

NephrectomyRobotic Surgical ProceduresAdultAgedFemaleHumansKidney NeoplasmsMaleMiddle AgedPeritoneumProspective StudiesRetroperitoneal SpaceTreatment Outcomepentafectaretroperitonealrobot assisted partial nephrectomytransperitonealtrifecta

Identifiers

PMID40421622
PMCPMC12107505

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.