ArticleJournal of applied clinical medical physics2025
Demonstration of an enhanced dosing pattern for debulking large and bulky unresectable tumors via differential hole-size spatially fractionated radiotherapy.
Article in Journal of applied clinical medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Implementation of VMAT-based lattice spatially fractionated radiation therapy (SFRT) across linac platforms: Practical considerations for QA and motion management.Journal of applied clinical medical physics · 2026Article
- Demonstration of an enhanced dosing pattern for debulking large and bulky unresectable tumors via differential hole-size spatially fractionated radiotherapy.Journal of applied clinical medical physics · 2025Article
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Authors and funding
3 authors.
Funding
Abstract
PURPOSE/
objectiveWe propose a novel lattice deployment for spatially fractionated radiotherapy (SFRT) treatments. In this approach, a larger diameter high-dose sphere is centrally placed in the bulky tumor mass and surrounded by smaller diameter high-dose spheres. MATERIALS/
methodsThirty SFRT patients (10 head and neck [HN], 10 abdominal/pelvis, and 10 chest/lung cases) treated with an MLC-based crossfire method were retrospectively analyzed. Eleven differential hole-size lattice patterns were benchmarked against the clinically delivered SFRT plans (1 cm diameter cylinders, 2 cm spacing) and the standard uniform lattice pattern (1.5 cm diameter spheres, 3 cm spacing). These patterns varied in core diameter (C: 2-4 cm), spacing (S: 2-4 cm), and peripheral diameter (P: 1-2 cm). In addition to peak-to-valley-dose ratio (PVDR), tumor dose metrics (D
results10 out of 11 differential hole-size patterns showed increases in D
conclusionAll differential hole-size SFRT replans were clinically acceptable, with C = 3 cm, S = 2 cm, and P = 1.5 cm providing the optimal setting for select tumors. Differential lattice patterns enhanced the ablative dose to the bulky tumors while restricting the maximum dose to adjacent critical organs.
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