Evidence map›Paper›PMID 40421456›Full record

ArticleFrontiers in physiology2025

Enhanced cerebral oxygenation during mental and physical activity in older adults is unaltered by amnestic mild cognitive impairment.

Stephanie Elbanna, Christopher Cortez, Elaina Smith, Jewelia Rattanavong, Sarah Ross, Geoffrey Kline, April Wiechmann, Hannah Dyson, Robert T Mallet, Xiangrong Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Stephanie ElbannaDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United States.
Christopher CortezDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United States.
Elaina SmithDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United States.
Jewelia RattanavongDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United States.
Sarah RossDepartment of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, United States.
Geoffrey KlineDepartment of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, United States.
April WiechmannDepartment of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, United States.
Hannah DysonDepartment of Internal Medicine, University of North Texas Health Science Center, Fort Worth, TX, United States.
Robert T MalletDepartment of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, TX, United States.
Xiangrong ShiDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The impact of amnestic mild cognitive impairment (aMCI) on cerebral oxygenation and cardiovascular responses to mental and physical challenges in elderly adults is unclear. This study compared the responses to mental (serial sevens test) and physical (isometric handgrip) challenges in older adults with vs. without aMCI. Methods: Thirty-one aMCI (71.5 ± 1.1 years old) and 30 cognitively normal (70.8 ± 1.1 years old) adults participated in the study. Heart rate (HR), mean arterial pressure (MAP), systemic arterial oxygen saturation (SaO Results: Cardiovascular and tissue oxygenation responses to testing were similar in the two groups. Although MAP increased similarly during the mental and physical challenges, increases in HR (P = 0.020), SaO Conclusion: The mental arithmetic challenge increased the metabolic demand of the prefrontal cortex to a greater extent than the physical task. Cerebral O

Indexed as

cerebral tissue oxygenationheart rate responseisometric handgripneurovascular couplingoxyhemoglobinserial sevens test

Identifiers

PMID40421456
PMCPMC12104240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.