Evidence map›Paper›PMID 40421455›Full record

ReviewFrontiers in physiology2025

The advances in acetylation modification in senescence and aging-related diseases.

Maiqi Xu, Wenbin Wang, Saien Lu, Mengyao Xiong, Tong Zhao, Yao Yu, Chunyu Song, Jinjing Yang, Naijin Zhang, Liu Cao and 3 more

Abstract readReview
In one paragraph

Review in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maiqi Xu *Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Wenbin Wang *Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Saien Lu *Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Mengyao Xiong *Department of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Tong ZhaoDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Yao YuDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Chunyu SongDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Jinjing YangDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Naijin ZhangDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Liu CaoInstitute of Health Sciences, China Medical University, Shenyang, Liaoning Province, China.
Guozhe SunDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Sichong ChenDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.
Pengbo WangDepartment of Cardiology, The First Hospital of China Medical University, Shenyang, Liaoning Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is a process in which organisms or cells undergo a decline in their functions. Epigenetic modification changes have been recognized as a senescence hallmark in both natural aging and stimulation-induced senescence. An acetylation modification is a dynamic process, which plays a crucial role in the senescence process through DNA stability, metabolism, and signaling pathways. We summarized the role and regulatory pathways of acetylation modifications in senescence. Various cell fate-determining proteins regulate multiple cellular processes through acetylation modifications. These processes interact and coordinate with each other, forming an integrated regulatory network framework that collectively drives cellular senescence

Indexed as

acetylation modificationagingDNA stabilitymitochondrial functionnetwork mechanismprotein homeostasis

Identifiers

PMID40421455
PMCPMC12104306

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.