Hemophagocytic Lymphohistiocytosis Complicating a Case of Drug-Induced Liver Injury Precipitated by Cephalexin: A Rare Consequence of Commonly Prescribed Medications.

Matthew T Newman, Thu Anne Mai, Joe McClanaghan, Nicholas Burley, Tamira Robinson, Yang Jiang, Amandeep Sahota

Abstract readCase Reports

In one paragraph

Article in Case reports in hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matthew T NewmanDepartment of Internal Medicine, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, USA.ORCID https://orcid.org/0000-0002-2091-8869

Thu Anne MaiDepartment of Gastroenterology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, USA.

Joe McClanaghanDepartment of Internal Medicine, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, USA.

Nicholas BurleyDepartment of Hematology and Medical Oncology, UCLA Medical Center Olive View, Sylmar, Los Angeles, California, USA.

Tamira RobinsonDepartment of Transplant Hepatology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, USA.

Yang JiangDepartment of Hematology and Medical Oncology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, USA.

Amandeep SahotaDepartment of Gastroenterology, Kaiser Permanente Los Angeles Medical Center, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Drug-induced liver injury (DILI) is a relatively rare clinical syndrome that accounts for a significant proportion of acute liver failure progressing to transplant in the United States. Some drugs such as acetaminophen are classically associated with a predictable pattern of DILI that can often be reversed with prompt administration of guideline-directed therapeutics. In other cases, commonly prescribed medications can lead to an unpredictable variant of DILI in certain vulnerable populations for which few guidelines on management exist, likely in part due to the heterogeneity of precipitating toxins. We report a case of idiosyncratic DILI caused by cephalexin that progressed to fulminant hemophagocytic lymphohistiocytosis (HLH) in a young and previously healthy patient, alongside our experiences with therapeutic management and outcomes guided by a multidisciplinary team.

Identifiers

PMID40421446

DOI10.1155/crhe/4600879

PMCPMC12105900

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.