Evidence map›Paper›PMID 40421429›Full record

ArticleJournal of the Endocrine Society2025

Serum Phoenixin Levels and Their Diagnostic Significance in Girls With Precocious Puberty.

Ye Yang, Jun Sun, Shuyi Yang, Siqing Li, Jingjing Zhang, Fei Zhu, Xiaoxiao Pan, Ying Wang, Xiaona Li, Hua Bai and 2 more

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In one paragraph

Article in Journal of the Endocrine Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ye YangPediatric Endocrinology Department, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.ORCID https://orcid.org/0009-0005-9554-424X
Jun SunPediatric Endocrinology Department, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.
Shuyi YangPediatric Endocrinology Department, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.
Siqing LiPediatric Endocrinology Department, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.
Jingjing ZhangPediatric Endocrinology Department, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.
Fei ZhuPediatric Endocrinology Department, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.
Xiaoxiao PanPediatric Endocrinology Department, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.
Ying WangPediatric Endocrinology Department, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.
Xiaona LiPediatric Endocrinology Department, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.
Hua BaiPediatric Endocrinology Department, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.
Peiliang LuoPediatric Endocrinology Department, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.ORCID https://orcid.org/0009-0007-0500-7550
Yingdi YuanPediatric Endocrinology Department, The First People's Hospital of Lianyungang, The Affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang 222000, China.ORCID https://orcid.org/0000-0001-8829-8726

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Phoenixin (PNX), a recently identified neuropeptide, is recognized for its role in reproduction. Objective: This study aims to explores serum phoenixin expression and its diagnostic value in girls with central precocious puberty (CPP). Methods: Girls visiting the Pediatric Endocrinology Department of Lianyungang First People's Hospital (February 2023-February 2025) were included and divided into 3 groups: CPP (n = 48), premature thelarche (PT) (n = 58), and healthy controls (NCs, n = 50). Serum phoenixin levels were measured via enzyme-linked immunosorbent assay and compared among groups. Spearman correlation analysis assessed variable relationships, and receiver operating characteristic (ROC) curves evaluated phoenixin's diagnostic value for CPP. Results: Serum PNX-14 levels of the CPP group (228.42 [193.29-277.22] pg/mL) were considerably higher relative to the PT group (192.58 [151.34-239.48] pg/mL) ( Conclusion: Serum PNX-14 is associated with CPP and reflects growth and pubertal development. It may serve as a potential biomarker for adjunct diagnosis of CPP in girls.

Indexed as

central precocious pubertygirlsphoenixin

Identifiers

PMID40421429
PMCPMC12105469

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.