Evidence map›Paper›PMID 40421415›Full record

Observational studyFrontiers in cellular and infection microbiology2025

Predicting ventilator-associated lower respiratory tract infection outcomes using sequencing-based early microbiological response: a proof-of-concept prospective study.

Ji Zhou, Qian Qian, Chuwei Jing, Jing Liu, Danni Wang, Mingyue Wang, Yuchen Ding, Dejian Gu, Wenyin Xia, Lili Tao and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ji Zhou *Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Qian Qian *Clinical Medicine School, Jiangsu Health Vocational College, Nanjing, China.
Chuwei Jing *Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Jing LiuClinical Medicine Research Institution, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Danni WangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Mingyue WangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Yuchen DingDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Dejian GuDepartment of Medicine, Geneplus-Beijing Co., Ltd., Beijing, China.
Wenyin XiaDepartment of Laboratory Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
Lili TaoDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN, United States.
Wenkui SunDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Ventilator-associated lower respiratory tract infections (VA-LRTIs) cause significant mortality. This study was assigned to explore the association between early microbiological responses defined by quantitative targeted amplicon-based next-generation sequencing (QtNGS) and clinical outcomes in patients with Measurements and main results: A prospective observational study including 34 participants was conducted to assess the probability of predicting clinical outcomes using sequencing-based early microbiological response. Bronchoalveolar lavage fluids (BALFs) were collected at admission and 3 days post-treatment from these patients for QtNGS to determine the relative quantification ratio (RQR) of Conclusions: The RQR of

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsPneumonia, Ventilator-AssociatedRespiratory Tract InfectionsAdultAgedAged, 80 and overBronchoalveolar Lavage FluidFemaleHigh-Throughput Nucleotide SequencingHumansMaleMiddle AgedPrognosisProspective StudiesROC CurveA. baumanniimicrobiological responseNGSVA-LRTIVAP

Identifiers

PMID40421415
PMCPMC12104225

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.