Evidence map›Paper›PMID 40421388›Full record

ArticleTransplant international : official journal of the European Society for Organ Transplantation2025

Urinary NGAL Outperforms

Esther N M de Rooij, Tirsa T van Duijl, Ellen K Hoogeveen, Fred P H T M Romijn, Friedo W Dekker, Cees van Kooten, Christa M Cobbaert, Johan W de Fijter

Abstract read
In one paragraph

Article in Transplant international : official journal of the European Society for Organ Transplantation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Serum α-Klotho and SIRT1 - Relationship with graft function, inflammation and hospitalization rates in kidney transplant recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2026
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Esther N M de RooijDepartment of Nephrology, Leiden University Medical Center, Leiden, Netherlands.
Tirsa T van DuijlDepartment of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands.
Ellen K HoogeveenDepartment of Nephrology, Leiden University Medical Center, Leiden, Netherlands.
Fred P H T M RomijnDepartment of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands.
Friedo W DekkerDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden, Netherlands.
Cees van KootenDepartment of Nephrology, Leiden University Medical Center, Leiden, Netherlands.
Christa M CobbaertDepartment of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Leiden, Netherlands.
Johan W de FijterDepartment of Nephrology, Leiden University Medical Center, Leiden, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recipients of donation after circulatory death (DCD) kidneys are at high risk for delayed graft function (DGF) due to severe ischemia-reperfusion injury. We compared urinary biomarkers in predicting the duration of DGF with the tubular function slope (TFS) as the gold standard. In 89 DCD kidney transplant recipients, urinary TIMP-2, IGFBP7, B2M, NGAL, KIM1, CXCL9, and UMOD were quantified by LC-MS/MS analysis on postoperative days (PODs) 1, 4 and 10. Interstitial fibrosis and tubular atrophy (IF/TA) were assessed with protocol biopsies at POD 10. TFS was calculated with

Indexed as

Delayed Graft FunctionKidney TransplantationLipocalin-2Radioisotope RenographyTechnetium Tc 99m MertiatideAdultAgedBiomarkersFemaleHumansKidneyMaleMiddle AgedBiomarkersLCN2 protein, humanLipocalin-2Technetium Tc 99m MertiatideDCD donationdelayed graft function (DGF)kidney transplantationNGALurinary biomarkers

Identifiers

PMID40421388
PMCPMC12104080

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.