ArticleCureus2025
Inappropriate Use of Proton Pump Inhibitors for Stress Ulcer Prophylaxis in a Tertiary Care Hospital: A Cross-Sectional Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- PPI Misuse in Bangladesh: Confronting a Silent Epidemic Through Deprescribing and Regulatory Reform-A Policy Perspective.Health science reports · 2026Article
- Ventilator-Associated Pneumonia (VAP) Prevention Bundle: A Multicenter Cross-Sectional Saudi Study to Assess Knowledge, Adherence, and Perceived Barriers Among ICU Practitioners in Hail Region.Pathogens (Basel, Switzerland) · 2026Article
- Evaluating a multifaceted stewardship intervention on proton pump inhibitor utilization: an interrupted time-series analysis of prescribing patterns in a northwest Chinese hospital.Frontiers in pharmacology · 2026Article
- Insights into stress ulcer prophylaxis among non-critically ill patients: a tertiary hospital perspective from Sudan.Journal of pharmaceutical health care and sciences · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough proton pump inhibitors (PPIs) are extensively used for acid-related disorders, their inappropriate administration for stress ulcer prophylaxis (SUP) in hospitalized patients remains a cause for concern. This study aimed to evaluate the extent of PPI misuse for SUP in a tertiary care setting, identify contributing factors, and assess adherence to clinical guidelines. METHODOLOGY: A cross-sectional study was conducted over one year, including hospitalized patients receiving PPIs for SUP without documented indications. Data were collected through medical record reviews and physician questionnaires to determine prescription patterns, indications, and adherence to guidelines. Statistical analysis was performed using SPSS (IBM Corp., Armonk, NY, USA), employing chi-square tests and descriptive statistics.
resultsAmong 274 patients, only 31.02% had appropriate indications for PPI use, while 68.98% received PPIs without meeting prophylactic criteria. Overall, 33.58% of prescriptions adhered to guidelines, whereas 66.42% deviated. The average duration of PPI use was 10.3 ± 4.7 days: 47.45% used PPIs for seven or fewer days, 31.02% for eight to 14 days, and 21.53% for more than 14 days. Guideline-based prescribing accounted for 35.77%, while 40.88% of prescriptions were attributed to defensive prescribing. Inappropriate PPI use was significantly associated with older age (p = 0.034) and ICU admission (p = 0.001).
conclusionPPI overuse for stress ulcer prevention is prevalent among hospitalized patients. Targeted interventions are needed to improve adherence to evidence-based guidelines and curb unnecessary prescribing, particularly in relation to defensive medical practices.
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