Evidence map›Paper›PMID 40421270›Full record

ArticleCase reports in gastroenterology

Hypoalbuminemia and Generalized Edema as the Presenting Symptoms of Celiac Disease in a Two-Year-Old Girl: A Case Report.

Michael R Weaver, William C Schultz, Ahmed Rafay Afzal, Kara L Oliver, Osama F Almadhoun

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Article in Case reports in gastroenterology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michael R WeaverDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.
William C SchultzDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.
Ahmed Rafay AfzalDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.
Kara L OliverDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.
Osama F AlmadhounDepartment of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Celiac disease (CD) is a systemic, immune-mediated enteropathy that occurs following dietary consumption of gluten in genetically susceptible individuals. The global prevalence of celiac disease is estimated to be approximately 1.4%, with variation based on age, sex, and geographic location. CD typically presents early in life with diarrhea, abdominal pain, abdominal distention, weight loss, and impaired growth. In severe cases, patients with CD can present in a state of celiac crisis (CC), classically characterized with profuse diarrhea and life-threatening metabolic derangements. Case Presentation: In this report, we discuss a 23-month-old girl in a state of CC who presented atypically with hypoalbuminemia, generalized edema, and constipation. Conclusion: Even in the presence of atypical symptoms, such as edema or constipation, CD should be considered as a differential diagnosis in pediatric patients with severe gastrointestinal disturbances. Additionally, we propose a revised definition of CC that is specific to the pediatric population.

Indexed as

Case reportCeliac crisisCeliac diseaseConstipationEdema

Identifiers

PMID40421270
PMCPMC12105830

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.