ReviewExperimental and therapeutic medicine2025
Role and research progress of histone modification in cardiovascular diseases (Review).
Review in Experimental and therapeutic medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Deciphering epigenetic regulation in cardiac developmental toxicity: Mechanisms and implications (Review).Molecular medicine reports · 2026Review
- Epigenetic advances in rheumatic heart disease.Journal of translational autoimmunity · 2025Review
- Non-coding RNAs in heart failure: epigenetic regulatory mechanisms and therapeutic potential.Frontiers in genetics · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As society evolves and lifestyles change, there has been a notable rise in the incidence of cardiovascular diseases due to a parallel rise in associated risk factors. In recent years, considerable research has been conducted on the impact of histone modifications in relation to these conditions. Processes such as acetylation, methylation and phosphorylation of histones, mediated by specific enzymes, are essential in the regulation of gene expression, which in turn influences cellular functions and the progression of diseases. Research shows that alterations in specific histone modifications are closely linked to the onset and advancement of cardiovascular conditions. For instance, significant variations in histone deacetylases and H3K27 methylation have been observed in cases of heart failure and myocardial ischemia-reperfusion injury. In the present review, it was aimed to summarize recent findings in this area, providing a foundation for further exploration of the mechanisms by which histone modifications contribute to cardiovascular diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.