ArticleFrontiers in pharmacology2025
Esmolol improves sepsis outcomes through cardiovascular and immune modulation.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Low-dose esmolol attenuates sepsis-induced myocardial injury: association with improved autophagic homeostasis and PI3K/Akt signaling.Journal of intensive care · 2026Article
- β-Adrenergic receptors as immunomodulators in T cells: mechanisms of neuroimmune crosstalk and pathophysiological implications.Molecular medicine (Cambridge, Mass.) · 2026Review
- Esmolol Alleviates Sepsis-Associated Myocardial Injury by Acting on the APAF1 and JAK2/STAT3 Inflammatory Pathways.Cardiovascular therapeutics · 2026Article
- Research progress on beta-blockers in the treatment of sepsis-induced cardiomyopathy: A mini review.SAGE open medicine · 2026Review
- Immunodynamic Disruption in Sepsis: Mechanisms and Strategies for Personalized Immunomodulation.Biomedicines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sepsis poses significant mortality risks. Esmolol, a β1-adrenergic blocker, may improve outcomes through cardiovascular and immune modulation. This study aims to evaluate the effects of Esmolol on survival rates, inflammatory markers, and immune function in sepsis patients. Methods: In this retrospective observational study, data from 268 sepsis patients were reviewed, and 125 met the inclusion criteria. These patients were divided into Esmolol and control groups. Data were collected from electronic health records, including survival rates, inflammatory markers (IL-6, PCT), and immune function markers (CD4 Results: The Esmolol group demonstrated significantly higher survival rates at both 14 days (80% vs. 41.67%, p < 0.01) and 28 days (75.38% vs. 30.00%, p < 0.01) compared to the control group. The median ICU stay was longer in the Esmolol group (12 days vs. 10 days, P = 0.045). Significant reductions in heart rate (P = 0.002), NE levels (P = 0.036), and inflammatory markers were observed in the Esmolol group. Additionally, Esmolol treatment resulted in bidirectional regulation of T-cell counts, increasing CD4 Conclusion: Esmolol improves survival rates and clinical outcomes in sepsis patients, particularly those with higher baseline immune function. The benefits are attributed to early and prolonged administration of Esmolol, highlighting its potential as a valuable addition to sepsis treatment protocols. Future multicenter trials are needed to confirm these findings and refine the use of β1AR in sepsis management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.