Evidence map›Paper›PMID 40421155›Full record

ReviewTranslational breast cancer research : a journal focusing on translational research in breast cancer2025

De-escalation of axillary interventions in the management of breast cancer patients following neoadjuvant systemic treatment.

Ashutosh Tondare, Mangesh A Thorat

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational breast cancer research : a journal focusing on translational research in breast cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ashutosh TondareMGM's Medical College and MCRI Superspecialty Hospital, Chhatrapati Sambhajinagar, India.
Mangesh A ThoratCentre for Cancer Screening, Prevention and Early Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.ORCID https://orcid.org/0000-0001-8673-5320

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of axillary surgery in the management of breast cancer continues to evolve as our understanding of breast cancer biology improves, coupled with an increasing availability and efficacy of systemic therapy options. In the current context, the main goal of axillary surgery is staging. In this review, we discuss the role of axillary surgery in patients receiving neoadjuvant systemic therapy and appraise the current state of de-escalation of axillary interventions. We argue that accuracy of limited axillary staging procedure is important, not so much from axillary control point of view but from the systemic undertreatment point of view. We suggest that comparative evaluation of different limited axillary staging procedures from oncological safety perspective should therefore not be based on local axillary control endpoint. We discuss the comparative diagnostic accuracy of sentinel lymph node biopsy (SLNB)

Indexed as

axillary radiotherapyde-escalationNeoadjuvant chemotherapy (NACT)sentinel lymph node biopsy (SLNB)targeted axillary dissection (TAD)

Identifiers

PMID40421155
PMCPMC12104960

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.