ReviewFrontiers in neuroscience2025
Biological engineering approaches for modulating the pathological microenvironment and promoting axonal regeneration after spinal cord injury.
Review in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- A Unified Framework for Spinal Cord Injury Repair: Metabolic-Nutritional Microenvironment Remodeling, Immune Modulation, and Neural Regeneration.Molecular neurobiology · 2026Review
- Efficacy and Safety of Fixed Dose Combination of Inosine Monophosphate, Agmatine Sulphate, and L-Carnosine (CGXNW) as Add-on Therapy for the Management of Spinal Cord Injury - A Randomized Controlled Clinical Trial.Journal of orthopaedic case reports · 2026Article
- Hydrogel-Based Biomaterials in Spinal Repair: Evaluating Mechanisms for IVDD, SCI, and Dural Regeneration.Journal of multidisciplinary healthcare · 2025Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Functional recovery following spinal cord injury (SCI) presents significant challenges and imposes a substantial burden on society. Current research primarily focuses on minimizing damage and promoting regeneration to enhance functional recovery after SCI. Following SCI, secondary injuries such as mitochondrial dysfunction, vascular rupture, inflammatory responses, and glial scarring occur in the lesion area, forming the pathological microenvironment. These factors expand the extent of damage, exacerbate injury severity, and severely impede axonal regeneration after SCI. Modulating the pathological microenvironment through various interventions may facilitate axonal regeneration and promote functional recovery after SCI. This article reviews the influence and research advancements in axon regeneration concerning mitochondrial dysfunction, inflammatory response, and glial scar formation after SCI. Additionally, it integrates insights from bioengineering to improve the pathological microenvironment, summarizing the progress in axon regeneration research. The review concludes with novel strategies for enhancing axon regeneration, offering fresh perspectives for future investigations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.