Evidence map›Paper›PMID 40421051›Full record

ArticleCytotechnology2025

Ameliorative potential of metformin in LPS and glutamate-induced neurotoxicity in N2a cell-line.

Deepshikha, Nikhila Shekhar, Sakshi Tyagi, Ajit Kumar Thakur

Abstract read
In one paragraph

Article in Cytotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Mitigation ofJournal of microbiology and biotechnology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

DeepshikhaNeuropharmacology Research Laboratory, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, 110 017 India.
Nikhila ShekharNeuropharmacology Research Laboratory, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, 110 017 India.
Sakshi TyagiNeuropharmacology Research Laboratory, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, 110 017 India.
Ajit Kumar ThakurNeuropharmacology Research Laboratory, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, 110 017 India.ORCID 0000-0002-1187-602X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aims to explore the potential of metformin to counteract the lethal effects of glutamate and lipopolysaccharide (LPS)- induced neurotoxicity in Neuro2a (N2a) cells, resembling CNS-comorbidities generally associated with metabolic disorders. Glutamate and LPS-induced N2a cell models were used to conduct the

Indexed as

GlutamateLPSMetforminNeuroinflammationNeurotoxicityOxidative stress

Identifiers

PMID40421051
PMCPMC12103449

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.