Evidence map›Paper›PMID 40421008›Full record

ArticleFrontiers in immunology2025

Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance.

Shanshan Liang, Wei Xu, Peiying Zhong, Chuanmin Tao, Li Zhang, Chengyao Jia

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shanshan Liang *Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Wei Xu *Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Peiying ZhongDepartment of Laboratory, 363 Hospital, Chengdu, China.
Chuanmin TaoDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Li ZhangDepartment of hematology, West China hospital, Sichuan University, Chengdu, China.
Chengyao JiaDepartment of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IgG4-related disease (IgG4-RD), an immune-mediated fibroinflammatory disorder, has few reports in combination with monoclonal gammopathy of undetermined significance (MGUS). Herein, we present a case of a 69-year-old woman with manifestations of left orbital occupation and visual acuity decline. Ancillary tests indicated persistent positivity of IgG4 antibody, and IgG4-RD-related ophthalmopathy was diagnosed based on the criteria. Concurrently, serum protein electrophoresis revealed an M protein level of 12.23 g/L. Immunofixation electrophoresis suggested a positive IgG λ-type M protein, and MGUS was diagnosed in conjunction with bone marrow smear and flow cytometry.

Indexed as

Eye DiseasesImmunoglobulin GImmunoglobulin G4-Related DiseaseMonoclonal Gammopathy of Undetermined SignificanceAgedFemaleHumansImmunoglobulin Gdiagnostic criteriaIgEIgG4-RD-related ophthalmopathymonoclonal gammaglobulinemia of undetermined significanceM protein

Identifiers

PMID40421008
PMCPMC12104068

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