Evidence map›Paper›PMID 40420824›Full record

ArticleEndocrinology2025

The Benefits of Estradiol on Cognitive Aging in Rats Are Independent From Its Effects on Cardiometabolic Health.

Christian Montanari, Emma L Dong, Shruti Srinivasan, Ana Paula De Oliveira Leite, Alyssa F Delarge, Matthieu J Maroteaux, Lucie D Desmoulins, Riva Menon, Alice B Walker, Sarah H Lindsey and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Christian MontanariPsychology Department, Tulane University, New Orleans, LA 70118, USA.ORCID 0000-0002-4178-285X
Emma L DongTulane Brain Institute, Tulane University, New Orleans, LA 70118, USA.
Shruti SrinivasanTulane Brain Institute, Tulane University, New Orleans, LA 70118, USA.
Ana Paula De Oliveira LeiteTulane Brain Institute, Tulane University, New Orleans, LA 70118, USA.
Alyssa F DelargePsychology Department, Tulane University, New Orleans, LA 70118, USA.
Matthieu J MaroteauxPsychology Department, Tulane University, New Orleans, LA 70118, USA.
Lucie D DesmoulinsTulane Brain Institute, Tulane University, New Orleans, LA 70118, USA.
Riva MenonTulane Brain Institute, Tulane University, New Orleans, LA 70118, USA.
Alice B WalkerTulane Brain Institute, Tulane University, New Orleans, LA 70118, USA.
Sarah H LindseyTulane Brain Institute, Tulane University, New Orleans, LA 70118, USA.
Andrea ZsombokTulane Brain Institute, Tulane University, New Orleans, LA 70118, USA.
Jill M DanielPsychology Department, Tulane University, New Orleans, LA 70118, USA.

Funding

Impact of hypertension and high-fat diet on mechanisms by which estradiol affects the hippocampal memory system.P01AG071746 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI Sarah Hoffmann Lindsey · 2022 to 2026
$17.1M
NIA NIH HHS P01 AG071746NIH HHS P01AG071746
6 · The paper itself

Abstract

Research in preclinical models of menopause indicates that exogenously administered estrogens positively affect cognitive aging. However, clinical evidence indicates that the effects of estrogen therapy on cognition are inconsistent and may be modulated by preexisting cardiometabolic conditions. The extent to which cardiometabolic health affects the cognitive outcomes of estrogen therapy remains unclear. This study aimed to determine whether variations in cardiometabolic health, both prior to and resulting from different estradiol treatment regimens, are related to the ability of estradiol to improve the cognitive aging trajectory in ovariectomized Long-Evans rats. Cognitive function and health status were assessed at age 10 months after which rats were ovariectomized and administered vehicle or various estradiol treatments. Rats were assessed again at 18 (middle age) and 22 (old age) months. Cognition was evaluated using a spatial memory radial-maze task. Health status was determined through body composition analysis (dual-energy x-ray absorptiometry), glucose tolerance testing, and blood pressure and heart rate measurements (tail-cuff plethysmography). Results demonstrated that both continuous ongoing estradiol treatment and a previous 40-day estradiol exposure (terminated long before testing) significantly improved the cognitive aging trajectory from middle to old age. However, only continuous estradiol treatment had positive effects on health measures; previous estradiol treatment provided no benefits to aging cardiometabolic systems. In contrast, a delayed estradiol treatment (initiated months after ovariectomy) provided no benefits for cognition but provided health benefits. Results indicated that estradiol effects on cognition in healthy aging rats are separate from and not secondary to its effects on cardiometabolic health.

Indexed as

AgingCognitionCognitive AgingEstradiolAnimalsBlood PressureBody CompositionFemaleHeart RateMaze LearningOvariectomyRatsRats, Long-EvansEstradiolagingcardiovascularestrogensmemorymenopausemetabolism

Identifiers

PMID40420824
PMCPMC12138191

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.