ArticleAnimal models and experimental medicine2025
A mouse model of lung ischemia-reperfusion injury with reversible left hilar entrapment.
Article in Animal models and experimental medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Barbaloin Alleviates Lung Ischemia-Reperfusion Injury by Dual-Targeting IL-6 and PNP.International journal of molecular sciences · 2026Article
- A mouse model of lung ischemia-reperfusion injury with reversible left hilar entrapment.Animal models and experimental medicine · 2025Article
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Authors and funding
5 authors.
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Abstract
Lung ischemia-reperfusion injury (LIRI), an acute lung injury syndrome triggered by lung transplantation or distal organ ischemia, has long been a difficult and hot issue in clinical research. In this study, we proposed a simple and less invasive reversible LIRI surgical protocol, achieved by improving the mouse left hilar entrapment model, which significantly improved the operability of the experiment and the reproducibility of the results. The protocol achieves precise control of the ischemic and reperfusion processes by visualizing transoral intubation, using reversible ligation of live knots to clamp the left hilar, and temporary closure of the thoracic cavity during ischemia. The reversible survival model we constructed not only provides a reliable tool to study the cellular and molecular mechanisms of LIRI but also can be used to assess the stage of injury regression, experimental pneumonia, and survival in mice. In addition, it simplifies the lung portal separation clamping operation for reversible clamping and provides an easy-to-learn visual tracheal intubation method that can be quickly mastered and replicated by beginners for consistent and reliable results.
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