Evidence map›Paper›PMID 40420686›Full record

ArticleBiochemistry2025

In Vivo Ribosome-Amplified MetaBOlism, RAMBO, Effect Observed by Real Time Pulse Chase, RTPC, NMR Spectroscopy.

Jianchao Yu, Nicholas Sciolino, Leonard Breindel, Qishan Lin, David S Burz, Alexander Shekhtman

Abstract read
In one paragraph

Article in Biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jianchao YuDepartment of Chemistry, University at Albany, State University of New York, Albany, New York 12222, United States.ORCID 0009-0000-5536-5929
Nicholas SciolinoDepartment of Chemistry, University at Albany, State University of New York, Albany, New York 12222, United States.
Leonard BreindelDepartment of Chemistry, University at Albany, State University of New York, Albany, New York 12222, United States.
Qishan LinRNA Epitranscriptomics & Proteomics Resource, University at Albany, State University of New York, Albany, New York 12222, United States.
David S BurzDepartment of Chemistry, University at Albany, State University of New York, Albany, New York 12222, United States.
Alexander ShekhtmanDepartment of Chemistry, University at Albany, State University of New York, Albany, New York 12222, United States.ORCID 0000-0003-2649-2675

Funding

Project 3: RAGE/DIAPH1 interactions and cellular stressP01HL146367 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SCHMIDT, ANN MARIE · 2019 to 2023
$12.5M
Real Time (RT) In-cell NMR technology to study protein interactions in live cellsR01GM085006 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI SHEKHTMAN, ALEXANDER · 2010 to 2021
$2.4M
Chemical Modifications to Wobble Uridines in tRNA Regulate Responses to StressR01GM143749 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI BEGLEY, THOMAS J, SHENG, JIA · 2022 to 2025
$1.4M
NHLBI NIH HHS P01 HL146367NIGMS NIH HHS R01 GM085006NIGMS NIH HHS R01 GM143749
6 · The paper itself

Abstract

Quinary interactions between proteins and ribosomes play an important role in regulating biological activity through a phenomenon termed the Ribosome-Amplified MetaBOlism, RAMBO, effect. This effect has been documented in vitro but not in vivo. Real time pulse chase, RTPC, NMR spectroscopy, coupled with isotopic flux analysis in

Indexed as

Escherichia coliEscherichia coli ProteinsRibosomesChloramphenicolGlycolysisKineticsMagnetic Resonance SpectroscopyNuclear Magnetic Resonance, BiomolecularPyruvate KinaseChloramphenicolEscherichia coli ProteinsPyruvate Kinase

Identifiers

PMID40420686
PMCPMC12177922

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.