Evidence map›Paper›PMID 40420470›Full record

ArticleBioanalysis2025

A rapid and sensitive UHPLC-MS/MS method for epalrestat detection in micro-volumes of human plasma for the first time.

Hong Chen, Kewei Liu, Jiawen Zhang, Xihong Zhao, Yatian Wang, Xiumei Lu, Feng Qin

Abstract read
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Article in Bioanalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hong ChenSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, P. R. China.ORCID 0009-0006-7840-1455
Kewei LiuSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, P. R. China.ORCID 0009-0007-5099-7450
Jiawen ZhangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, P. R. China.ORCID 0009-0000-2705-2300
Xihong ZhaoSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, P. R. China.ORCID 0009-0004-8144-0581
Yatian WangSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, P. R. China.ORCID 0009-0007-4970-338X
Xiumei LuSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, P. R. China.ORCID 0000-0001-9186-9905
Feng QinSchool of Pharmacy, Shenyang Pharmaceutical University, Shenyang, Liaoning Province, P. R. China.ORCID 0000-0001-8562-7280

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimA rapid and sensitive ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) method was developed and validated for epalrestat detection in human plasma. MATERIALS AND

methodsA triple quadrupole tandem mass spectrometer equipped with an electrospray ionization (ESI) source was used to quantify epalrestat and the internal standard epalrestat-d RESULTS AND

conclusionThe retention time of epalrestat was 0.92 min and the entire run time was only 2.00 min. The calibration curve was linear in the range 10.0-8.00 × 10

Indexed as

Tandem Mass SpectrometryThiazolidinesChromatography, High Pressure LiquidHumansLimit of DetectionReproducibility of ResultsRhodanineepalrestatRhodanineThiazolidinesdetectionEpalrestatmicrosampleplasmaUHPLC-MS/MS

Identifiers

PMID40420470
PMCPMC12160602

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.