ArticleEnvironmental science & technology2025
Comparative Assessment of Wastewater-Based Surveillance Normalization Methods to Improve Pathogen Monitoring in Rural Sewersheds.
Article in Environmental science & technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Wastewater-Based Surveillance of Human Papillomavirus Genotype Diversity.JAMA network open · 2026Article
- Coupled epidemiological and wastewater modeling at the urban scale: A case study for Munich.iScience · 2026Article
- Toward a quality-managed operational architecture for wastewater surveillance of zoonotic and emerging pathogens.Applied and environmental microbiology · 2026Review
- Influence of Sampling Strategies and Disease Prevalence on SARS-CoV-2 Detection Dynamics in Wastewater Surveillance.Viruses · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many in-sewer dynamics that can impact the fidelity of wastewater-based surveillance results remain understudied. Some conventional approaches for normalizing pathogen signals in sewersheds may not be appropriate when there is substantial inflow and infiltration (I&I). Our objective for this study was to evaluate the effect of multiple normalization approaches on wastewater pathogen signals at the WWTP influent and across a small rural sewershed (<3000 people) with different levels of I&I. We collected wastewater samples monthly, from 2022 to 2023, from the wastewater treatment plant (WWTP) influent and 11 additional sewer system nodes with well-characterized I&I impacts. We quantified concentrations of SARS-CoV-2, norovirus GII, and rotavirus at the WWTP influent and subsewershed sites, and compared normalization approaches using flow, population, physicochemical parameters (COD, TSS, NH
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.