Evidence map›Paper›PMID 40420306›Full record

ArticleBMC pediatrics2025

Educational interventions and contextual factors for optimising antibiotic prescription in paediatric uncomplicated acute respiratory tract infections in primary care: scoping review of reviews.

Usue Elizondo-Alzola, Claudio Rocha, Leire Leache, Montserrat León-García, Luis Carlos Saiz, Ivan Solà, Camila Montesinos-Guevara, Adriana-Gabriela Meade, Andrea Boldú, Ignasi Bolíbar and 2 more

Abstract readScoping Review
In one paragraph

Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Usue Elizondo-AlzolaInstitut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain.ORCID 0000-0002-3808-9894
Claudio RochaCentro Cochrane Iberoamericano, Institut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain.ORCID 0000-0003-4221-3883
Leire LeachePharmacy and Services Sub-Directorate, Navarre Health Service, Pamplona, Navarre, Spain.ORCID 0000-0003-2272-7086
Montserrat León-GarcíaInstitut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain.ORCID 0000-0001-8567-4685
Luis Carlos SaizNavarra Institute for Health Research (IdiSNA), Pamplona, Navarre, Spain.ORCID 0000-0002-9143-5709
Ivan SolàCentro Cochrane Iberoamericano, Institut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain.ORCID 0000-0003-0078-3706
Camila Montesinos-GuevaraCentro de Investigación en Epidemiología Clínica y Salud Pública (CISPEC), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito, Ecuador.ORCID 0000-0001-6763-3644
Adriana-Gabriela MeadeCentro Cochrane Iberoamericano, Institut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain.ORCID 0000-0002-7572-3524
Andrea BoldúCentro Cochrane Iberoamericano, Institut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain.ORCID 0009-0001-3138-5754
Ignasi BolíbarCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.ORCID 0000-0002-4529-1935
Ena Niño-de-GuzmánCentro Cochrane Iberoamericano, Institut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain. ena.ninodeguzman@gmail.com.ORCID 0000-0001-6587-2780
Pablo Alonso-CoelloCentro Cochrane Iberoamericano, Institut de Recerca Sant Pau (IR Sant Pau), Barcelona, Spain. palonso@santpau.cat.ORCID 0000-0002-8001-8504

Funding

Fundació la Marató de TV3 295/U/2018
6 · The paper itself

Abstract

backgroundInappropriate antibiotic prescription in paediatric uncomplicated acute respiratory tract infections (ARTIs) in primary care (PC) settings contributes to antimicrobial resistance. We aimed (1) to identify and describe educational interventions and their components to optimise antibiotic prescription for paediatric uncomplicated ARTIs in PC, and (2) to map contextual factors that may influence antibiotic prescription and the implementation of interventions.

methodsWe searched three electronic databases (Medline, CINAHL and Epistemonikos) to identify reviews on the effectiveness of educational interventions and contextual factors, for optimising antibiotic prescription (Concept) in paediatric uncomplicated ARTIs (Population) in PC (Context). We included reviews that reported explicitly the search strategy used. Two previously calibrated reviewers independently screened the literature, extracted data, and assessed the methodological limitations. We applied the "best-fit framework synthesis approach", based on the main constructs of the Consolidated Framework for Implementation Research, and coded the data deductively by groups of analysis for reviews reporting effectiveness (e.g. antibiotic or consultation rate) or by thematic synthesis for reviews reporting contextual factors (e.g. healthcare professionals' knowledge) based on a logic model.

resultsWe identified 11 reviews evaluating education intervention and their characteristics, including 182 interventions with at least one educational component (educational intervention plus another type, educational or non-educational), with 136 providing information on characteristics and effectiveness. Successful interventions' characteristics were related to the kind of intervention (e.g. communication skill training), mode of delivery (e.g. face to face), and target population (e.g. parents/caregivers). From the 22 reviews on contextual factors, healthcare professionals' attitudes and perceptions, knowledge, and health system and professionals' teams' organization (inner setting), were the most frequent themes; less information was available on individuals´ characteristics (parents/children) and on outer setting (e.g. policies).

conclusionWe identified a large number of heterogeneous educational interventions. Combining educational interventions plus another type targeting both parents/caregivers and healthcare professionals, and considering their needs and their context may improve antibiotic prescribing in children. Further research is needed on consultation rate, knowledge, attitudes, and satisfaction outcomes and contextual factors, as well as on the cost-effectiveness of the interventions. REGISTRATION: The protocol was published in OSF iRegistries in May 2021 (Elizondo-Alzola, U).

Indexed as

Anti-Bacterial AgentsInappropriate PrescribingPractice Patterns, Physicians'Primary Health CareRespiratory Tract InfectionsAcute DiseaseChildHumansAnti-Bacterial AgentsAntibiotic prescriptionChildrenEducational interventionsPaediatricsPrimary careRespiratory tract infectionsScoping review.

Identifiers

PMID40420306
PMCPMC12105144

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.