Evidence map›Paper›PMID 40420242›Full record

ArticleActa neuropathologica communications2025

Lack of junctional adhesion molecule (JAM)-B traps CD8 T cells in CNS border zones and ameliorates autoimmune neuroinflammation.

Javier Pareja, Sidar Aydin, Mara Zbinden, Elisa Bouillet, Niklas Zollinger, Vidusiya Theivendram, Amal Fahmi, Petr Pleskač, Sara Barcos, Felix Paas and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Single-cell landscape of sex-specific drivers of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Javier Pareja *Theodor Kocher Institute, University of Bern, Bern, Switzerland. javier.pareja.roman@gmail.com.
Sidar Aydin *Theodor Kocher Institute, University of Bern, Bern, Switzerland.ORCID 0000-0001-7791-7931
Mara ZbindenTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Elisa BouilletTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Niklas ZollingerTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Vidusiya TheivendramTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Amal FahmiTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Petr PleskačTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Sara BarcosTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Felix PaasTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Florencia KlosterTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Aida Muñoz BlázquezTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Nicolas FontaDepartment of Pathology and Immunology, Division of Clinical Pathology, University and University Hospitals of Geneva, Geneva, Switzerland.
Doron MerklerDepartment of Pathology and Immunology, Division of Clinical Pathology, University and University Hospitals of Geneva, Geneva, Switzerland.
Urban DeutschTheodor Kocher Institute, University of Bern, Bern, Switzerland.
Britta EngelhardtTheodor Kocher Institute, University of Bern, Bern, Switzerland. britta.engelhardt@unibe.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endothelial blood-brain barrier (BBB) tightly controls T cell entry into the central nervous system (CNS). T cell extravasation across the BBB involves a multi-step cascade with a predominant role of α4β1-integrins. In contrast to CD4 T cells, α4β1-integrin mediated CD8 T cell interaction with the BBB was proposed to involve the tight junction protein junctional adhesion molecule (JAM)-B. Here, we made use of ODC-OVA mice expressing ovalbumin as neo-self-antigen in oligodendrocytes that is solely visible to CD8 T cells, allowing to investigate CD8 T cell-mediated autoimmune neuroinflammation. We generated JAM-B-deficient ODC-OVA mice (ODC-OVA; JAM-B

Indexed as

CD8-Positive T-LymphocytesCell Adhesion MoleculesCentral Nervous SystemEncephalomyelitis, Autoimmune, ExperimentalNeuroinflammatory DiseasesAnimalsBlood-Brain BarrierMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicCell Adhesion MoleculesBBBCD8 T cellCNSGlia limitansJAM-BNeuroinflammation

Identifiers

PMID40420242
PMCPMC12105289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.