Evidence map›Paper›PMID 40420229›Full record

ArticleArthritis research & therapy2025

Functional work disability from the perspectives of persons with systemic lupus erythematosus: a qualitative thematic analysis.

Behdin Nowrouzi-Kia, Aaron S Howe, Anson Li, Jeremy Tan, Natalia Saade-Cleves, Kevon Jules, Malak Sadek, Ali Bani-Fatemi, Antonio Avina-Zubieta, Mary T Fox and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis research & therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Behdin Nowrouzi-KiaReSTORE Lab, Department of Occupational Science and Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, 500 University Avenue, Toronto, ON, M5G 1V7, Canada. behdin.nowrouzi.kia@utoronto.ca.ORCID 0000-0002-5586-4282
Aaron S HoweReSTORE Lab, Department of Occupational Science and Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, 500 University Avenue, Toronto, ON, M5G 1V7, Canada.
Anson LiReSTORE Lab, Department of Occupational Science and Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, 500 University Avenue, Toronto, ON, M5G 1V7, Canada.
Jeremy TanReSTORE Lab, Department of Occupational Science and Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, 500 University Avenue, Toronto, ON, M5G 1V7, Canada.
Natalia Saade-ClevesReSTORE Lab, Department of Occupational Science and Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, 500 University Avenue, Toronto, ON, M5G 1V7, Canada.
Kevon JulesUniversity of Toronto, Toronto, ON, Canada.
Malak SadekUniversity of Western Ontario, London, ON, Canada.
Ali Bani-FatemiReSTORE Lab, Department of Occupational Science and Occupational Therapy, Temerty Faculty of Medicine, University of Toronto, 500 University Avenue, Toronto, ON, M5G 1V7, Canada.
Antonio Avina-ZubietaUniversity of British Columbia / Arthritis Research Canada, British Colombia, Canada.
Mary T FoxSchool of Nursing, York University, Toronto, ON, Canada.
William ShawSchool of Medicine, University of Connecticut, Farmington, CT, USA.
Derek HaalandThe Waterside Clinic, Barrie, ON, Canada.
Janet PopeSt. Joseph's Health Care, London, ON, Canada.
Paul R FortinCentre de recherche du CHU Québec, Université Laval (CHUL), Québec, Québec, Canada.
Kathleen S BinghamCentre for Mental Health, University Health Network, Toronto, ON, Canada.
Christine PeschkenUniversity of Manitoba, Winnipeg, MB, Canada.
Jennifer ReynoldsMary Pack Arthritis Program, Vancouver Arthritis Centre, Vancouver, BC, Canada.
Catherine IvoryThe Ottawa Hospital Arthritis Centre, Division of Rheumatology, Ottawa, ON, Canada.
Dafna D GladmanSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Canada.
Murray B UrowitzUniversity of Toronto, Toronto, ON, Canada.
Jorge Sanchez-GuerreroSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Canada.
Lily S H LimUniversity of Manitoba, Winnipeg, MB, Canada.
Stephanie KeelingDivision of Rheumatology, University of Alberta, Edmonton, AB, Canada.
Patti KatzUniversity of California, San Francisco, San Francisco, USA.
Mahta KavkanSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Canada.
Dennisse BonillaSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Canada.
Wils NielsenUniversity of Toronto, Toronto, ON, Canada.
Zahi ToumaSchroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSystemic lupus erythematosus (SLE) disease symptoms that can significantly restrict work ability and work participation resulting in reduced mental well-being. This study investigates the significant impact of work participation and disability on the mental wellbeing, health-related quality of life, and disease-related outcomes in individuals with SLE.

methodsWith the objective of creating an SLE-related functional profile rooted in work disability (WD) prevention, 46 SLE patients were purposively recruited from Canadian medical centres. Through semi-structured interviews guided by a WD prevention framework, factors associated with WD and lived experiences of SLE-related WD were qualitatively explored. Braun and Clarke's six-stage inductive thematic analysis was used to organize the data.

resultsMost participants experienced some form of work disability across their employment history related to their clinical manifestations of SLE, including hospitalizations, physical limitations, fatigue, and neurocognitive symptoms (e.g. brain fog). Thematic analysis revealed three key themes: (a) the influence of illness experience on work, (b) the stigmatization of illness disclosure, and (c) the availability of workplace resources/accommodations. Participants emphasized the desirability of work with reduced physical and mental demands, increased personal control, and workplace flexibility to prevent WD.

conclusionThe study underscores the need for a collaborative, multi-component, and multidisciplinary intervention targeting psychosocial and workplace factors to establish a goal-oriented preventative framework, potentially improving WD outcomes in SLE individuals.

Indexed as

EmploymentLupus Erythematosus, SystemicPersons with DisabilitiesAdultCanadaDisability EvaluationFemaleHumansMaleMiddle AgedQualitative ResearchQuality of LifeDisease-related outcomesEmployment historyHealth-related quality of lifeLived experiencesMental well-beingMultidisciplinary interventionsSystemic lupus erythematosusWork disability

Identifiers

PMID40420229
PMCPMC12105366

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.