Evidence map›Paper›PMID 40420206›Full record

ArticleChinese medicine2025

Electroacupuncture exerts antipruritic and anti-inflammatory effects on atopic dermatitis by activating CB2 receptor.

Wenqiang Ge, Xin Liu, Xuefei Hu, Yang Yang, Hongxiang Chen, Ouyang Zhan-Mu, Shiying Lin, Yanzhen Li, Peiling Li, Qing Tian and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chinese medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenqiang GeSchool of Basic Medical Science, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China.
Xin LiuDepartment of Dermatology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xuefei HuSchool of Basic Medical Science, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China.
Yang YangSchool of Basic Medical Science, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China.
Hongxiang ChenDepartment of Dermatology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ouyang Zhan-MuSchool of Basic Medical Science, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China.
Shiying LinDepartment of Dermatology Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yanzhen LiSchool of Basic Medical Science, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China.
Peiling LiSchool of Basic Medical Science, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China.
Qing TianSchool of Basic Medical Science, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China. tianq@hust.edu.cn.
Xianghong JingInstitute of Acupuncture and Moxibustion China Academy of Chinese Medical Sciences (CACMS), Beijing, China. jxhtjb@263.net.
Man LiSchool of Basic Medical Science, Key Laboratory of Neurological Diseases of Hubei Province and National Education Ministry, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China. liman73@mails.tjmu.edu.cn.ORCID http://orcid.org/0000-0003-4041-0437

Funding

China Postdoctoral Science Foundation 0106510062China Postdoctoral Science Foundation 0106510145Fundamental Research Funds for Central Universities of the Central South University ZZ201813005National Natural Science Foundation of China 82205275National Natural Science Foundation of China 82305002，81674057Scientific research project of Huazhong University of Science and Technology Union Shenzhen Hospital No.YN2021001Shenzhen Knowledge Innovation Program JCYJ20210324112213036
6 · The paper itself

Abstract

backgroundThe therapeutic benefits of electroacupuncture (EA) for atopic dermatitis (AD) are recognized, yet the underlying mechanisms remain elusive. Given the side effects associated with clinical CB2 receptor (CB2R) agonists used in AD treatment, our study seeks to elucidate EA's role in modulating CB2R in lesional skin and its impact on antipruritic and anti-inflammatory responses using an AD mouse model.

methodsThe AD model was induced with MC903, and EA was applied to'Qu chi'(LI11) and'He gu'(LI4) acupoints, corresponding to the neck dermatome. Mice were assessed for scratching behavior and scoring atopic dermatitis score every other day. Immunohistochemistry and immunofluorescence evaluated epidermal thickness, inflammatory cell infiltration, and CB2R expression. Meanwhile, RT-qPCR detected the expression of inflammatory factors, their receptors, and cannabinoid metabolizing enzymes. The study used both wild-type and CB2R knockout (CB2R

resultsEA treatment effectively mitigated chronic itching and AD-like symptoms, especially the proliferation of mast cells and CD4

conclusionEA exerts therapeutic effects on persistent itch and skin inflammation in AD mice by activating CB2R, thereby inhibiting mast cell and CD4

Indexed as

Atopic dermatitisCB2 receptorChronic itchElectroacupunctureInflammation

Identifiers

PMID40420206
PMCPMC12105266

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.