Evidence map›Paper›PMID 40420153›Full record

Trial reportThe international journal of behavioral nutrition and physical activity2025

Accelerometer measurement error in a randomized physical activity intervention trial in breast cancer survivors was nondifferential but attenuated the intervention effect.

Laura Q Rogers, Douglas Midthune, Kevin Dodd, Heather Bowles, Edward McAuley, Kerry S Courneya, Brian Barrett, Spiro Razis, Gary R Hunter, Stephen J Carter and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The international journal of behavioral nutrition and physical activity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00929617 (Enhancing Physical Activity Adherence After Breast Cancer Diagnosis), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00929617 nacompletednot on this map

Enhancing Physical Activity Adherence After Breast Cancer Diagnosis (BEAT Cancer Study II)

TypeinterventionalSponsorUniversity of Alabama at BirminghamRan2009 to 2017Enrolled374ConditionsBreast CancerArmsExperimental 1: exercise with 2 counseling types, Usual Care - written materials
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Laura Q RogersDivision of General Internal Medicine and Population Science, Department of Medicine, Heersink School of Medicine, University of Alabama at Birmingham, 1720 2ndAve S, MT 614, Birmingham, AL 35294-4410, Birmingham, AL, USA. lqrogers@uabmc.edu.ORCID http://orcid.org/0000-0003-4216-8381
Douglas MidthuneBiometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.
Kevin DoddBiometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.
Heather BowlesBiometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.
Edward McAuleyDepartment of Health and Kinesiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Kerry S CourneyaFaculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.
Brian BarrettInformation Management Services, Inc., Calverton, MD, USA.
Spiro RazisInformation Management Services, Inc., Calverton, MD, USA.
Gary R HunterDepartment of Nutrition Sciences, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, USA.
Stephen J CarterDepartment of Kinesiology, School of Public Health - Bloomington, Indiana University, Bloomington, IN, USA.
Raymond J CarrollDepartment of Statistics, Texas A&M University, College Station, TX, USA.
Victor KipnisBiometry Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, MD, USA.

Funding

Why is the prevalence of obesity so high in U.S. Southern States? Regional predictors of BMI and obesity treatment response.P30DK056336 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARBARA A GOWER · 2000 to 2026
$31.9M
Enhancing physical activity after breast cancer diagnosis: randomized trialR01CA136859 · NCI · SOUTHERN ILLINOIS UNIVERSITY SCH OF MED · PI ROGERS, LAURA Q · 2009 to 2012
$2.6M
Enhancing physical activity after breast cancer diagnosis: randomized trialU01CA136859 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ROGERS, LAURA Q · 2012 to 2015
$2.0M
NIDDK NIH HHS P30 DK056336NIH HHS P30DK056336NIH HHS R01CA136859NIH HHS U01CA136859
6 · The paper itself

Abstract

backgroundPhysical activity reduces morbidity and mortality risk in cancer survivors, but a meaningful proportion of this vulnerable population are physically inactive. Targeted interventions can help cancer survivors adopt a more active lifestyle, but the efficacy of these interventions must be rigorously evaluated in randomized controlled intervention trials. A major barrier to such trials involves the difficulty in obtaining unbiased estimates of physical activity in free-living conditions.

methodsWe conducted a randomized controlled trial of a 3-month intervention designed to increase physical activity vs. usual care in breast cancer survivors (n = 316). The primary outcome was change in physical activity as estimated by hip-worn accelerometer (MTI/Actigraph, models GT1M and GT3X). The trial included a sub-study (n = 106) wherein unbiased measures of total energy expenditure (doubly labeled water), and resting energy expenditure (indirect calorimetry) were collected. A linear mixed measurement error model characterized the structure of measurement error in accelerometry-estimated physical activity energy expenditure (PAEE), and corrected for bias in the estimated intervention effect due to measurement error.

resultsBias in the accelerometer estimates was related to true PAEE (p < 0.001) and baseline body mass index (p < 0.001) but was not related to age (p = 0.13). After correcting for measurement error, the estimated intervention effect at 3 months (change from baseline in PAEE in the intervention arm minus change in the control arm) was 77 kcal/day (95% confidence interval (CI) = 31-125), compared to 48 kcal/day (95% CI = 22-75) when measurement error was ignored. These results indicate a 20% (21%) increase in PAEE kcal x d

conclusionsMeasurement error in accelerometer-estimated PAEE can attenuate the effect size related to intervention effects in randomized controlled trials of physical activity interventions. Sub-studies that collect unbiased measures of PAEE can be used to correct for this short-coming.

trial registrationClinicalTrials.gov; NCT00929617; registered 06/26/2009; https://clinicaltrials.gov/study/NCT00929617.

Indexed as

AccelerometryBreast NeoplasmsCancer SurvivorsExerciseAdultAgedEnergy MetabolismFemaleHumansMiddle AgedDifferential errorExerciseIndirect calorimetryIntervention trialsMeasurement errorOncology

Identifiers

PMID40420153
PMCPMC12105316

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.