ArticleBMC musculoskeletal disorders2025
Clinical and microbiological profile of spondylodiscitis: a retrospective analysis.
Article in BMC musculoskeletal disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Methodological Framework for Global Expert Consensus on Musculoskeletal Infection: Establishing the ICM 2025 Recommendations.Global spine journal · 2026Article
- Article
- Pyogenic Spondylodiscitis: Predictors of Microbiological Yield from Biopsy in a Tertiary Hospital.Medicina (Kaunas, Lithuania) · 2025Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSpondylodiscitis is a rare infectious disease with rising incidence in recent years. From 2005 till 2021 the incidence of Spondylodiscitis rose by 104%. Given its potential to cause complications and mortality, it demands greater attention. Epidemiological data and predisposing factors can vary significantly across different geographical regions, suggesting that data from Iran may differ from those in other parts of the world. This study aims to evaluate the demographic, clinical, laboratory, and imaging characteristics of spondylodiscitis patients treated at Loghman Hakim Hospital in Tehran. Additionally, it seeks to analyze the treatment outcomes and complications associated with the disease.
methodsWe conducted a retrospective analysis of 65 adult patients diagnosed with spondylodiscitis over the past decade (2012-2022). The data collected encompassed demographic characteristics, underlying diseases, clinical presentations, laboratory and radiological findings, microbiological results, treatment approaches, and outcomes.
resultsThe study included 65 adult patients with a mean age of 55.12 years, showing a slight male predominance (58.5%). Spondylodiscitis was community-acquired in 49.2% of cases and hospital-acquired postoperatively in 50.8%. The lumbosacral spine was the most affected region (47.4%). Staphylococcus aureus was the most frequently isolated microorganism (28.2%), followed by Mycobacterium tuberculosis. Complications included abscess formation in 49.2% of patients and multiorgan failure in 6.2%, resulting in death. Treatment primarily involved antibiotic therapy, with surgical intervention in select cases. Poor outcomes were observed in patients with unidentified microorganisms and those with longer delays in diagnosis.
conclusionsSpondylodiscitis is associated with significant morbidity and a high rate of complications, particularly in cases with delayed diagnosis. Early diagnosis, appropriate antimicrobial therapy, and surgical intervention when necessary are crucial for improving patient outcomes. This study highlights the need for ongoing research to optimize diagnostic pathways and develop long-term management strategies for spondylodiscitis.
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