Evidence map›Paper›PMID 40419993›Full record

ArticleBMC psychiatry2025

The Eating Disorders Genetics Initiative 2 (EDGI2): study protocol.

Natasha Berthold, Casey M MacDermod, Laura M Thornton, Richard Parker, Shantal Anid Cortés Morales, Liv Hog, Hannah L Kennedy, Jerry Guintivano, Patrick F Sullivan, James J Crowley and 36 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06594913 (Eating Disorders Genetics Initiative 2), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06594913 recruitingnot on this map

Eating Disorders Genetics Initiative 2

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2024 to 2027Enrolled20,000ConditionsAnorexia Nervosa, Bulimia Nervosa, Binge-Eating Disorder, Avoidant Restrictive Food Intake DisorderArmsEating disorder diagnosis group
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Natasha Berthold *Department of Psychiatry, University of North Carolina at Chapel Hill, #7160, 101 Manning Drive, Chapel Hill, CBNC, 27599 - 7160, USA.
Casey M MacDermod *Department of Psychiatry, University of North Carolina at Chapel Hill, #7160, 101 Manning Drive, Chapel Hill, CBNC, 27599 - 7160, USA.
Laura M ThorntonDepartment of Psychiatry, University of North Carolina at Chapel Hill, #7160, 101 Manning Drive, Chapel Hill, CBNC, 27599 - 7160, USA.
Richard ParkerQIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Locked Bag 2000, Brisbane, QLD, 4029, Australia.
Shantal Anid Cortés MoralesResearch Department, Comenzar de Nuevo, Monterrey, Mexico.
Liv HogDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
Hannah L KennedyDepartment of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Jerry GuintivanoDepartment of Psychiatry, University of North Carolina at Chapel Hill, #7160, 101 Manning Drive, Chapel Hill, CBNC, 27599 - 7160, USA.
Patrick F SullivanDepartment of Psychiatry, University of North Carolina at Chapel Hill, #7160, 101 Manning Drive, Chapel Hill, CBNC, 27599 - 7160, USA.
James J CrowleyDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
Jessica S JohnsonDepartment of Psychiatry, University of North Carolina at Chapel Hill, #7160, 101 Manning Drive, Chapel Hill, CBNC, 27599 - 7160, USA.
Andreas BirgegårdDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
Bengt T FundínDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
Emma FransDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
Jiayi XuDivision of Molecular Psychiatry, Department of Psychiatry, Yale University, New Haven, CT, USA.
Michaela Pettie Ngāti PūkengaDepartment of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Allison L MillerDepartment of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Mariana Valdez AguilarDepartment of Psychiatry, University of North Carolina at Chapel Hill, #7160, 101 Manning Drive, Chapel Hill, CBNC, 27599 - 7160, USA.
Sarah BarakatInsideout Institute for Eating Disorders, The University of Sydney, Sydney, Australia.
Mohamed AbdulkadirDepartment of Public Health, National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Jennifer P WhiteDepartment of Psychiatry, University of North Carolina at Chapel Hill, #7160, 101 Manning Drive, Chapel Hill, CBNC, 27599 - 7160, USA.
Janne T LarsenDepartment of Public Health, National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Elsie TrujilloResearch Department, Comenzar de Nuevo, Monterrey, Mexico.
Bertha WintermanResearch Department, Comenzar de Nuevo, Monterrey, Mexico.
Ruyue ZhangDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
Rachel LawsonSouth Island Eating Disorders Service, Health NZ Te Whatu Ora, Christchurch, New Zealand.
Stephen WonderlichCenter for Biobehavioral Research, Sanford Health, Fargo, ND, USA.
Joseph WonderlichCenter for Biobehavioral Research, Sanford Health, Fargo, ND, USA.
Lauren M SchaeferCenter for Biobehavioral Research, Sanford Health, Fargo, ND, USA.
Philip S MehlerACUTE Center for Eating Disorders and Severe Malnutrition, Denver Health and Hospital Authority, Denver, CO, USA.
Judy OakesACUTE Center for Eating Disorders and Severe Malnutrition, Denver Health and Hospital Authority, Denver, CO, USA.
Marina FosterACUTE Center for Eating Disorders and Severe Malnutrition, Denver Health and Hospital Authority, Denver, CO, USA.
Jennifer GaudianiGaudiani Clinic, Denver, CO, USA.
Eva Trujillo Chi Vacuán *Research Department, Comenzar de Nuevo, Monterrey, Mexico.
Emilio J Compte *Research Department, Comenzar de Nuevo, Monterrey, Mexico.
Liselotte V Petersen *Department of Public Health, National Centre for Register-Based Research, Aarhus University, Aarhus, Denmark.
Zeynep Yilmaz *Department of Psychiatry, University of North Carolina at Chapel Hill, #7160, 101 Manning Drive, Chapel Hill, CBNC, 27599 - 7160, USA.
Nadia Micali *Center for Eating and Feeding Disorders Research, Mental Health Services of the Capital Region of Denmark, Psychiatric Centre Ballerup, Copenhagen, Denmark.
Jennifer Jordan *Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Martin A Kennedy *Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud - , Monterrey, Mexico.
Sarah Maguire *Insideout Institute for Eating Disorders, The University of Sydney, Sydney, Australia.
Laura M Huckins *Division of Molecular Psychiatry, Department of Psychiatry, Yale University, New Haven, CT, USA.
Yi Lu *Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
Lisa Dinkler *Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
Nicholas G Martin *QIMR Berghofer Medical Research Institute, Royal Brisbane Hospital, Locked Bag 2000, Brisbane, QLD, 4029, Australia.
Cynthia M Bulik *Department of Psychiatry, University of North Carolina at Chapel Hill, #7160, 101 Manning Drive, Chapel Hill, CBNC, 27599 - 7160, USA. cynthia_bulik@med.unc.edu.

Funding

North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
1/3 Eating Disorders Genetics Initiative 2 (EDGI2)R01MH136149 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CYNTHIA M BULIK, Laura Marianne Huckins · 2024 to 2026
$5.1M
3/3 Eating Disorders Genetics Initiative 2 (EDGI2)R01MH136156 · NIMH · KAROLINSKA INSTITUTE · PI Lisa Dinkler, Lu Yi · 2024 to 2026
$1.5M
2/3 Eating Disorders Genetics Initiative 2R01MH136157 · NIMH · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI NICHOLAS G MARTIN · 2024 to 2026
$1.5M
NCATS NIH HHS UL1 TR001111NIMH NIH HHS R01 MH136149NIMH NIH HHS R01MH136149NIMH NIH HHS R01 MH136156NIMH NIH HHS R01MH136156NIMH NIH HHS R01 MH136157NIMH NIH HHS R01MH136157
6 · The paper itself

Abstract

backgroundThe Eating Disorders Genetics Initiative 2 (EDGI2) is designed to explore the role of genes and environment in anorexia nervosa, bulimia nervosa, binge-eating disorder, and avoidant/restrictive food intake disorder (ARFID) with a focus on broad population representation and severe and/or longstanding illness.

methodsA total of 20,000 new participants (18,700 cases and 1,300 controls) will be ascertained from the United States (US), Mexico (MX), Australia (AU), Aotearoa New Zealand (NZ), Sweden (SE), and Denmark (DK). Comprehensive phenotyping and genotyping will be performed for participants in US, MX, AU, NZ, and SE using the EDGI2 questionnaire battery and participant saliva samples. In DK, case identification and genotyping will be through the National Patient Register and bloodspots archived near birth. Case-control and case-case genome-wide association studies will be conducted within EDGI2 and enhanced via meta-analysis with external data from the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED). Additional analyses will explore genetic correlations between eating disorders (EDs) and other psychiatric and metabolic traits, calculate polygenic risk scores (PRS), and leverage functional biology to evaluate clinical outcomes. Moreover, analyzing PRS for patient stratification and linking identified risk loci to clinically relevant phenotypes highlight the potential of EDGI2 for clinical translation. DISCUSSION: EDGI2 is a global expansion of the EDGI study to increase sample size, increase participant representation across multiple ancestral backgrounds, and to include ARFID. ED genetics research has historically lagged behind other psychiatric disorders, and EDGI2 is designed to rapidly advance the study of the genetics of the major EDs. Exploring EDs at both the diagnostic level and the symptom level will provide an unprecedented look at the genetic architecture underlying EDs.

trial registrationEDGI2 is a registered clinical trial: clinicaltrials.gov NCT06594913. https://clinicaltrials.gov/study/NCT06594913 (posted September 19, 2024).

Indexed as

Feeding and Eating DisordersGene-Environment InteractionAdolescentAdultAustraliaCase-Control StudiesFemaleGenome-Wide Association StudyGenotypeHumansMaleNew ZealandPhenotypeResearch DesignUnited StatesAnorexia nervosaAvoidant/restrictive food intake disorderBinge-eating disorderBulimia nervosaGenome-wide associationPsychiatric genetics

Identifiers

PMID40419993
PMCPMC12105188

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.