ArticleBMC cardiovascular disorders2025
Association between triglyceride glucose-waist to height ratio (TyG-WHtR) and hypertension in adults aged 18-60: a cross-sectional study.
Article in BMC cardiovascular disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed.
- Triglyceride-glucose waist-to-height ratio in relation to prevalent and incident multimorbidity: cross-sectional and prospective evidence from four national studies.Cardiovascular diabetology · 2026Article
- Clinical Obesity and Insulin Resistance Assessed Based on SHBG Levels and HOMA-IR, TyG-Waist Circumference (TyG-WC), TyG-Waist to Height Ratio (TyG-WHtR), and TyG-Waist to Hip Ratio (TyG-WHR) Values in Young Caucasian Women with Polyendocrine Metabolic Ovarian Syndrome (PMOS).Journal of clinical medicine · 2026Article
- Triglyceride-Glucose-Waist-to-Height Ratio Index and Left Ventricular Diastolic Function in Military Athletes.JACC. Advances · 2026Article
- Triglyceride-glucose indices distinguish clinical from preclinical obesity in US adults: A cross-sectional study.Medicine · 2026Article
- Associations between novel triglyceride-glucose-related indices and the incidence of hypertension among Chinese middle-aged and elderly adults: a nationwide prospective cohort study.Cardiovascular diabetology. Endocrinology reports · 2025Article
- Association of the triglyceride-glucose index and its combination with obesity indices with cardio-renal-metabolic multimorbidity: two decades of follow-up in the Tehran Lipid and Glucose Study.Cardiovascular diabetology · 2025Article
- Association between triglyceride-glucose index and its obesity indicators with hypertension in postmenopausal women: a cross-sectional study.Frontiers in nutrition · 2025Article
- The association between triglyceride glucose-waist-to-height ratio and non-alcoholic fatty liver disease in adults aged over 60 in the United States: a cross-sectional study.Frontiers in public health · 2025Article
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10 authors.
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Abstract
backgroundThis study aimed to explore the association between TyG and the prevalence of hypertension in US adults aged 18-60.
methodData was obtained from the National Health and Nutrition Examination Survey (NHANES) covering the circles from 2009 to 2018, involving 12,309 adults aged 18 to 60. The biomarkers studied in this article included weight, body mass index (BMI), waist circumference (WC), weight-adjusted waist index (WWI), waist-to-height ratio (WHtR), triglyceride-glucose index (TyG), triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), triglyceride glucose-weight (TyG-Weight), and triglyceride glucose-waist to height ratio (TyG-WHtR). Participants were categorized into a non-Hypertension group (n = 7,076) and a Hypertension group (n = 5,233). A weighted multiple logistic regression model was employed to evaluate the association between biomarkers and hypertension. Restricted cubic splines (RCS) were utilized to examine the non-linear association between biomarkers and the risk of developing hypertension. Threshold effect analysis was used to determine the inflection point. Receiver operating characteristic (ROC) curves were generated to assess the predictive performance of biomarkers for hypertension. Additionally, subgroup and interaction analyses were conducted to confirm the reliability of the associations observed.
resultOur analysis revealed that after adjusting for multiple variables, the risk of hypertension increased by 12% for each unit increase in TyG-WHtR (P < 0.001). The RCS results showed a positive nonlinear association between TyG-WHtR and hypertension, with an inflection point of 5.79. Similar associations were also observed with WWI, WHtR, and TyG. The ROC curve analysis demonstrated that TyG-WHtR had the best predictive performance for hypertension (AUC: 0.6946, 95% CI: 0.6853-0.7039, Cut-off Value: 4.831, all P for comparison < 0.001). Subgroup analysis revealed that the association between TyG-WHtR and hypertension remains robust (all P for interaction > 0.05).
conclusionThere is a significant association between WWI, WHtR, TyG, and TyG-WHtR with hypertension in American adults aged 18 to 60, with TyG-WHtR demonstrating the best predicted performance. CLINICAL TRIAL NUMBER: Not applicable.
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