Observational studyMedicine2025
Association between the aggregate index of systemic inflammation and chronic kidney disease in adults: A cross-sectional study of NHANES 2007-2018.
Observational study in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Positive relationship between an aggregate index of systemic inflammation and stress urinary incontinence: a nationwide cross-sectional analysis.Translational andrology and urology · 2026Article
- Joint association of estimated glucose disposal rate and aggregate index of systemic inflammation with mortality in general population: a nationwide prospective cohort study.Cardiovascular diabetology · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic kidney disease (CKD) is closely linked to chronic inflammation, which plays a key role in its progression. The study aimed to investigate the association between the aggregate index of systemic inflammation (AISI) and CKD prevalence. We analyzed data from the National Health and Nutrition Examination Survey, which was conducted between 2007 and 2018. Multivariate logistic regression analyses were used to assess the independent relationship between AISI and CKD. Nonlinear relationships between AISI and CKD were examined through smooth curve fitting and threshold effect analyses. A total of 24,386 adult participants were included. After controlling for possible confounding variables, a significant positive association between AISI and CKD was identified (OR = 1.05, [95% CI: 1.03-1.07], P < .001). Subgroup analyses and interaction tests revealed significant differences in this association across diabetes strata (P < .05). Smoothing curve analysis demonstrated a nonlinear positive correlation between AISI and CKD. Moreover, threshold analysis revealed a saturation effect with an inflection point at 720 (1000 cells/μL). Below this threshold (AISI < 720, 1000 cells/μL), AISI was significantly positively associated with CKD, while no significant association was observed above the threshold (AISI > 720, 1000 cells/μL). These findings reveal a notable positive correlation between AISI and CKD among adults in the United States, with an inflection point at 720 (1000 cells/μL). The AISI shows potential as an indicator associated with CKD, but further comprehensive prospective studies are needed to confirm its role in CKD development and its utility in clinical practice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.