Evidence map›Paper›PMID 40419903›Full record

ReviewMedicine2025

Juvenile pemphigus vulgaris: A narrative review.

Shyamkumar Sriram, Mambakkam Jayakanth, Tanveer Alam, Shazina Saeed, Shamimul Hasan

Abstract readReview
In one paragraph

Review in Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shyamkumar SriramDepartment of Rehabilitation and Health Services, College of Health and Public Service, University of North Texas, Denton, TX.
Mambakkam JayakanthDepartment of Internal Medicine, Patiala Heart Institute, Patiala, India.
Tanveer AlamDepartment of Biomedical Dental Sciences, College of Dentistry, Al Baha University, Alaqiq, Al Baha, Kingdom of Saudi Arabia.
Shazina SaeedAmity Institute of Public Health & Hospital Administration, Amity University, Noida, Uttar Pradesh, India.
Shamimul HasanDepartment of Oral Medicine and Radiology, Faculty of Dentistry, Jamia Millia Islamia, New Delhi, India.ORCID 0000-0001-6832-9150

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pemphigus vulgaris is a chronic autoimmune dermatosis that primarily affects the skin and mucous membranes. Juvenile pemphigus vulgaris (JPV), a pediatric variant of pemphigus vulgaris, displays unusual features that may mimic other mucosal lesions. This similarity leads to diagnostic and therapeutic difficulties, often causing delays in diagnosis. Primary treatment consists of systemic corticosteroids and immunosuppressive agents, with biological therapies, such as rituximab, emerging as potential alternatives. Timely diagnosis and treatment are essential to improve prognosis and reduce complications related to long-term immunosuppressive therapy. A comprehensive electronic and manual literature search was conducted using various databases to consolidate the existing literature on JPV, focusing on its epidemiology, pathogenesis, clinical presentation, diagnosis, treatment options, and long-term outcomes in pediatric patients. A detailed review focusing on JPV has been conducted over the last 10 years (2014-2024). A literature review identified 37 cases of JPV in 16 studies. Owing to the rarity of JPV, much of the available evidence relies on case reports and case series, resulting in poorly defined response rates to different treatment options. Additionally, long-term monitoring of patients with disease recurrence is lacking. By identifying gaps in the current knowledge and offering a comprehensive overview, this review seeks to enhance awareness and guide future research and management strategies for JPV.

Indexed as

PemphigusAdolescentChildHumansImmunosuppressive AgentsRituximabImmunosuppressive AgentsRituximabautoimmunehistopathologyjuvenile pemphigus vulgarispemphigusvesiculobullous disease

Identifiers

PMID40419903
PMCPMC12114023

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.