Evidence map›Paper›PMID 40419838›Full record

ArticleJournal of molecular histology2025

miR-29a-3p compositely regulates the COL6A6/PTEN-PI3K/Akt/CUX1 feedback loop to participate in the proliferation and invasion of pituitary adenomas.

Zhuohui Liu, Xiufu Liao, Hexiang Zhao, Biao Ruan, Fengfeng Jia, Xuzhi He, Ruiqing Long

Abstract read
In one paragraph

Article in Journal of molecular histology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhuohui Liu *Department of Otolaryngology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.
Xiufu Liao *Department of Otolaryngology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.
Hexiang ZhaoDepartment of Neurosurgery, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.
Biao RuanDepartment of Otolaryngology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.
Fengfeng JiaDepartment of Otolaryngology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China.
Xuzhi HeDepartment of Neurosurgery, Daping Hospital, Army Medical University, Chongqing, 400042, Chongqing, China. hxzh2024@tmmu.edu.cn.
Ruiqing LongDepartment of Otolaryngology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, Yunnan, China. longruiqing@ydyy.cn.

Funding

Department of Science and Technology of Yunnan province - Kunming Medical University joint project 202101AY070001-082National Natural Science Foundation of China 82160513Project of Yunnan Province to build a Science and Technology Innovation Center for South and Southeast Asia 202303AP140005
6 · The paper itself

Abstract

Pituitary adenoma (PA) is one of the most common intracranial tumors, and owing to its special biological morphology and behavior, there is currently no effective treatment. miRNAs play crucial roles as diagnostic indicators and targets for the treatment of numerous cancer types. The objective of this research was to explore how miR-29a-3p influences the development of PA. We collected 25 pairs of PA tissue and normal pituitary tissue, followed by the subcutaneous injection of 5 × 10

Indexed as

AdenomaMicroRNAsPituitary NeoplasmsAnimalsCell Line, TumorCell MovementCell ProliferationFeedback, PhysiologicalFemaleGene Expression Regulation, NeoplasticHomeodomain ProteinsHumansMaleMiceMice, NudeNeoplasm InvasivenessHomeodomain ProteinsMicroRNAsMIRN29a microRNA, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPTEN PhosphohydrolasePTEN protein, humanRNA-Binding ProteinsCOL6A6miR-29a-3pPI3K/Akt/CUX1 signaling pathwayPituitary adenomaPTEN

Identifiers

PMID40419838
PMCPMC12106155

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.