Trial reportEuropean journal of nutrition2025
Glucoregulatory status modulates acute cognitive effects of repeated low-glycaemic snack consumption in older adults: a decentralized randomized controlled trial.
Trial report in European journal of nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05801731 (A Decentralized Study on Dietary Influences on Cognitive Functions), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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A Decentralized Study on Dietary Influences on Cognitive Functions
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study examined the effects of differential postprandial glucose responses on cognition in healthy older adults in a real-life setting. We hypothesised that consumption of a lower GI snack would have favourable effects on cognitive functioning and that this effect would be more pronounced in individuals with better glucoregulatory status.
methodsTwenty-eight healthy adults, aged 50-65 years, underwent two intervention periods of three consecutive test days, consuming either a low-GI snack or a control snack twice a day in a cross-over design. Cognitive performance and self-reported cognitive ability, mood, and appetite were measured six times on each of the six test days using a mobile application. Continuous glucose monitoring (CGM) occurred throughout the study. Glycated haemoglobin (HbA1c) and fasting glucose levels were taken as markers of glucoregulatory status.
resultsConsumption of the low-GI snack led to blunted post-prandial glucose responses but did not affect cognitive functioning. Significant interactions between the snack effect and glucoregulatory status were observed for Spatial Memory (p < 0.01), Symbol Search (p < 0.05), Composite Cognition score (p < 0.05), and a trend for subjective cognitive ability (p = 0.07), indicating poorer effects of the low GI snack in subjects with poorer glucoregulation. Fluctuations in blood glucose parameters did not mediate the cognitive effects of the snacks or cognitive function fluctuations throughout the test days.
conclusionWe demonstrated that poorer glucoregulatory status negatively affected the cognitive responses to a low-GI snack intervention. This interaction between glucoregulatory status and treatment response was detectable in non-diabetic subjects with normal to mildly compromised glucose regulation.
trial registrationNCT05801731, 24-03-2023.
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