Evidence map›Paper›PMID 40419709›Full record

ArticleMikrochimica acta2025

Development of a label-free electrochemical immunosensor based on self-assembled peptide-templated Au/Cu bimetallic nanozymes for sensitive detection of carcinoembryonic antigen (CEA).

Linyou Mao, Mengfei Li, Zihao Li, Yonghai Feng, Lei Liu, Rong Qin, Liang Yuan

Abstract read
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Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linyou MaoInstitute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang, 212013, P.R. China.
Mengfei LiInstitute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang, 212013, P.R. China.
Zihao LiInstitute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang, 212013, P.R. China.
Yonghai FengInstitute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang, 212013, P.R. China.
Lei LiuInstitute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang, 212013, P.R. China.
Rong QinDepartment of Medical Oncology, The Affiliated People's Hospital of Jiangsu University, Zhenjiang Clinical Medical College of Nanjing Medical University, Zhenjiang, 212000, P.R. China. jiangsu.qinrong@163.com.
Liang YuanInstitute for Advanced Materials, School of Materials Science and Engineering, Jiangsu University, Zhenjiang, 212013, P.R. China. yuanliang_24@ujs.edu.cn.

Funding

Jiangsu Provincial Traditional Chinese Medicine Science and Technology Development Program MS2024119National Natural Science Foundation of China 22004051Natural Science Foundation of Jiangsu Province BK20180858Research Project of Jiangsu University Affiliated People's Hospital YP2023005Scientific Research Starting Foundation for Senior Talent at Jiangsu University 18JDG025
6 · The paper itself

Abstract

Carcinoembryonic antigen (CEA) is a clinically significant biomarker for early-stage cancer diagnosis and therapeutic monitoring. Conventional immunoassays, while effective, suffer from limitations in stability, sensitivity, and procedural complexity. In this work, we report a label-free nanozyme electrochemical biosensor (nanoE-EB) integrating self-assembled peptide-templated Au/Cu bimetallic nanozymes for selective and sensitive CEA detection, eliminating labeling steps. The amphiphilic peptide i

Indexed as

Biosensing TechniquesCarcinoembryonic AntigenElectrochemical TechniquesMetal NanoparticlesPeptidesCopperGoldHumansImmunoassayLimit of DetectionCarcinoembryonic AntigenCopperGoldPeptidesBimetallic nanozymeCarcinoembryonic antigenLabel-free detectionModified glassy carbon electrodeNanozyme-based electrochemical biosensorPeptide self-assemblySquare wave voltammetry

Identifiers

PMID40419709

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.