ArticleCommunications biology2025
Burst of gyrification in the human brain after birth.
Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Early‑life head circumference is causally associated with adult executive function through cortical surface area expansion.Developmental cognitive neuroscience · 2026Article
- AI segmentation requires accounting for brain size to maintain performance on developmental MRI cohorts.bioRxiv : the preprint server for biology · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Nature communications · 2026Article
- Neurovariability as a signature of adaptive brain function.Brain structure & function · 2026Review
- Antenatal Opioid Exposure and Cerebral Cortical Maturation in Newborns.JAMA network open · 2026Article
- Advances in automated fetal brain MRI segmentation and biometry: Insights from the FeTA 2024 challenge.Medical image analysis · 2026Article
- Biophysical modeling of anatomically realistic prenatal cortical folding development.Research square · 2026Article
- Perinatal brain growth and autistic traits in toddlers.Translational psychiatry · 2025Article
- Data quality biases normative models derived from fetal brain MRI.Imaging neuroscience (Cambridge, Mass.)Article
- Voxel-based and surface-based morphometric analyses reveal cortical-subcortical structural abnormalities and cognitive correlates in drug-naïve SeLECTS.Frontiers in neurologyArticle
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Authors and funding
11 authors.
Funding
Abstract
Gyrification, the intricate folding of the brain's cortex, begins mid-gestation and surges dramatically throughout the perinatal period. Yet, a critical factor has been largely overlooked in neurodevelopmental research: the profound impact of birth on brain structure. Leveraging the largest known perinatal MRI dataset-819 sessions spanning 21 to 45 postconceptional weeks-we reveal a burst in gyrification immediately following birth (~37 weeks post-conception), amounting to half the entire gyrification expansion occurring during the fetal period. Using state-of-the-art, homogenized imaging processing tools across varied acquisition protocols, and applying a regression discontinuity design approach that is novel to neuroimaging, we provide the first evidence of a sudden, birth-triggered shift in cortical development. Investigation of additional cortical features confirms that this effect is uniquely confined to gyrification. This finding sheds light onto the understanding of early brain development, suggesting that the neurobiological consequences of birth may hold significant behavioral and physiological relevance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.