Evidence map›Paper›PMID 40419679›Full record

ArticleScientific reports2025

Plasma inflammation-related proteins associated with anxiety and depression disorders in IBD patients.

Min Si Zhou, Wan Ru Zhang, Yan Dang, Fang Xu, Chen Yue Xu, Zhan Wang, Chun Sai Er Wang, Si Ying Zhu, Peng Li, Jing Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Min Si Zhou *Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China.
Wan Ru Zhang *Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China.
Yan DangDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China.
Fang XuDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China.
Chen Yue XuDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China.
Zhan WangDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China.
Chun Sai Er WangDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China.
Si Ying ZhuDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China.
Peng LiDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China.
Jing WuDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China. wujing36youyi@ccmu.edu.cn.
Hai Yun ShiDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, State Key Laboratory of Digestive Health, National Clinical Research Center for Digestive Disease, Beijing, China. shihaiyun1016@gmail.com.

Funding

Beijing Science and Technology Program Z211100002921028Capital's Funds for Health Improvement and Research CFH2022-2-2025 and 2020-4-2085National Key Research and Development Program of China 2022YFC3602104
6 · The paper itself

Abstract

Up to 25-35% of patients with inflammatory bowel disease (IBD) suffer from anxiety or depression. Mood disorders are correlated with activated inflammatory response. However, changes of inflammation-related proteins in IBD patients with anxiety or depression disorders are still unclear. We aimed to depict the plasma proteomics characteristics of IBD patients with anxiety or depression. Adult patients diagnosed with IBD were prospectively enrolled, and the clinical data were obtained. The Hospital Anxiety and Depression Scale (HADS) was used to assess anxiety or depression levels. OLINK panel (Target 96 Inflammation) was used to quantify the plasma levels of inflammation-related proteins. Among the involved 142 IBD patients (median age 39.5, 42.96% female), 41 were comorbid with anxiety or depression symptoms. The levels of anxiety and depression symptoms in active phase group were significantly higher than those in quiescent group (P = 0.020). The anxiety and depression levels of IBD patients were positively correlated with fatigue levels (r = 0.713, P < 0.001), and negatively correlated with sleep quality (r = 0.499, P < 0.001) and quality of life (r =-0.692, P < 0.001). Plasma levels of 92 inflammation-related proteins were measured in 61 IBD patients. Up-regulated levels of fibroblast growth factor 23 (FGF-23) were found in IBD patients with anxiety or depression disorders, with an area under the curve (AUC) of 0.67(95%CI:0.53-0.81, P = 0.031). The plasma levels of C-C motif chemokine 20 (CCL20) and C-X-C motif chemokine 1 (CXCL1) were up-regulated in IBD patients with anxiety or depression, respectively, and the corresponding AUCs were 0.68 (95%CI:0.54-0.82, P = 0.036) and 0.70(95%CI:0.56-0.84, P = 0.017). Correlation analysis showed that the levels of anxiety and depression symptoms in IBD patients were negatively correlated with plasma Delta/Notch-like epidermal growth factor-related receptor (DNER) (r=-0.253, P = 0.047) and interleukin-8 (IL-8) (r=-0.275, P = 0.031) levels, and were positively correlated with the plasma levels of CXCL1 (r = 0.290, P = 0.022) and FGF-23 (r = 0.290, P = 0.022). In addition, negative correlation was found between plasma DNER levels and Mayo clinical scores in ulcerative colitis (UC) patients (r=-0.464, P = 0.001). Mood disorders are closely related to disease flare of IBD patients. The increasing levels of anxiety and depression in IBD patients are accompanied by graver fatigue, worse sleep quality and lower quality of life. Inflammation-related immune regulation is associated with the development of emotional disorders in IBD patients.

Indexed as

AnxietyAnxiety DisordersDepressive DisorderInflammationInflammatory Bowel DiseasesAdultBiomarkersDepressionFemaleHumansMaleMiddle AgedProteomicsQuality of LifeBiomarkersInflammatory bowel diseaseMood disordersPlasma proteomics

Identifiers

PMID40419679
PMCPMC12106643

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