Evidence map›Paper›PMID 40419667›Full record

Observational studyScientific reports2025

Association of circulating levels of anti-CarP antibodies with disease activity, disability and radiological damage in rheumatoid arthritis patients: an open-label, observational study.

Milica Markovic, Corrado Campochiaro, Branislava Glisic, Milan Petronijevic, Gorica Ristic, Ivan Stanojevic, Danilo Vojvodic, Naomi Viapiana, Marco Matucci-Cerinic, Lorenzo Dagna

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Milica MarkovicClinic for Internal Medicine, Rheumatology Division, Clinical Center of Montenegro, Podgorica, Montenegro. milica.markovic@unifi.it.
Corrado CampochiaroUnit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy.
Branislava GlisicDepartment of Rheumatology and Clinical Immunology, Medical Faculty of the Military Medical Academy, University of Defense, Belgrade, Serbia.
Milan PetronijevicDepartment of Rheumatology and Clinical Immunology, Medical Faculty of the Military Medical Academy, University of Defense, Belgrade, Serbia.
Gorica RisticDepartment of Rheumatology and Clinical Immunology, Medical Faculty of the Military Medical Academy, University of Defense, Belgrade, Serbia.
Ivan StanojevicMedical Faculty of the Military Medical Academy, Institute for Medical Research of the Military Medical Academy, University of Defense, Belgrade, Serbia.
Danilo VojvodicMedical Faculty of the Military Medical Academy, Institute for Medical Research of the Military Medical Academy, University of Defense, Belgrade, Serbia.
Naomi ViapianaUnit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy.
Marco Matucci-CerinicUnit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy.
Lorenzo DagnaUnit of Immunology, Rheumatology, Allergy and Rare Diseases (UnIRAR), IRCCS Ospedale San Raffaele and Vita-Salute San Raffaele University, Milan, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoantibodies directed against carbamylated proteins (anti-CarP) have been recently identified as predictors for RA development. The aim of this study was to determine the positivity of anti-CarP antibodies in a real-life cohort of RA patients and their association with radiological damage, disability and disease activity. In this open-label, observational, cross-sectional study 69 RA patients and 16 healthy controls (HC) were recruited. The study was approved by institutional Ethical Committee. Circulating levels of anti-CarP antibodies were determined by commercial ELISA anti-CarP quantitative sandwich immunoassay. Articular X-rays were evaluated to define the presence of bone erosions. Disease activity (DAS28-CRP) and disability (HAQ-DI) were assessed. Pearson χ

Indexed as

Arthritis, RheumatoidAutoantibodiesAdultAgedCase-Control StudiesCross-Sectional StudiesFemaleHumansMaleMiddle AgedRadiographySeverity of Illness IndexAutoantibodiesAnti-CarP antibodiesAutoantibodiesBiomarkersRheumatoid arthritis

Identifiers

PMID40419667
PMCPMC12106665

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.