ArticleScientific reports2025
Comparative efficacy of single vs. double autologous platelet-rich plasma ovarian injections for improving ovarian response in poor ovarian responders.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Platelet-rich plasma and folliculogenesis: a systematic mechanistic review and computational pathway analysis.Frontiers in reproductive health · 2026Pooled it
- Intra-ovarian injection of platelet-rich plasma in patients with poor ovarian response; a randomized controlled clinical trial.Journal of ovarian research · 2026Trial
- Bilateral ovarian abscesses following platelet-rich plasma injection for "ovarian rejuvenation": a case report.F&S reports · 2026Article
- Progress in research on the effects of Platelet-Rich Plasma (PRP) ovarian injection on early ovarian reserve dysfunction and premature ovarian insufficiency.Journal of ovarian research · 2026Review
- Research trends on platelet-rich plasma in improving ovarian dysfunction: A bibliometric and visualization analysis.Regenerative therapy · 2025Article
- Platelet-Rich Plasma in Reproductive Endocrinology: Mechanisms and Clinical Applications for Ovarian Reserve, PCOS, and Endometrial Receptivity.Biomedicines · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Poor ovarian response (POR) is a challenge in reproductive medicine, often leading to suboptimal outcomes in IVF/ICSI cycles. Autologous platelet-rich plasma (PRP) injections have emerged as a potential therapy to enhance ovarian function. This study aims to compare the efficacy of single versus double PRP ovarian injections in improving ovarian reserve, response to stimulation, and IVF/ICSI outcomes in women with POR. This before-and-after study was conducted at the Reproductive Center of the Sixth Affiliated Hospital of Sun Yat-sen University. Seventy-one women diagnosed with POR (POSEIDON group 3 or 4), characterized by anti-Müllerian hormone (AMH) levels below 1.2 ng/mL and fewer than five antral follicles, who had completed at least one IVF/ICSI cycle before and after PRP treatment were included. Participants received intraovarian injections of autologous PRP (2-2.5 mL per ovary) via transvaginal ultrasound guidance, either once or twice as determined clinically. We evaluated changes in ovarian reserve markers (AMH and antral follicle count [AFC]) and IVF/ICSI outcomes, such as the number of retrieved oocytes and quality embryos. Comparative analysis between single and double injections utilized the difference (Δ) between post- and pre-treatment values. PRP treatment resulted in significant improvements in AMH levels (from 0.33 ± 0.24 ng/mL to 0.43 ± 0.29 ng/mL, p = 0.005) and AFC (from 2.62 ± 1.09 to 3.80 ± 1.95, p < 0.001). Both single and double PRP injections significantly increased the number of retrieved oocytes (2.32 ± 1.80 vs. 3.59 ± 2.00, p < 0.001) and high-quality embryos (0.73 ± 1.08 vs. 1.28 ± 1.21, p = 0.002). Subgroup analysis indicated no significant differences in ΔAMH, ΔAFC, or IVF/ICSI outcomes between single and double treatments. However, the increase in AMH levels reached statistical significance only after double PRP injection, not after single injection. Autologous PRP ovarian injections significantly improve ovarian reserve parameters, the number of oocytes retrieved and high-quality embryos in women with POR. A single PRP injection is as effective as double injections, suggesting a more cost-effective and simpler protocol for clinical application.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.