Evidence map›Paper›PMID 40419610›Full record

ArticleScientific reports2025

Co-exposure to inhaled tungsten particles and low-dose gamma rays: neurotoxicological outcome in rats.

Théo Fréchard, Florence Bachelot, Véronique Ménard, Chloé Brizais, Léo Macé, Christelle Elie, Nicolas Cailler Gruet, Théo Teulade, Chloé Havet, Frédéric Voyer and 5 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Théo FréchardAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/LRTOX, F-92262, Fontenay-aux-Roses Cedex, France.
Florence BachelotAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/LRTOX, F-92262, Fontenay-aux-Roses Cedex, France.
Véronique MénardUniversité Paris Cité, Inserm, CEA, Stabilité Génétique Cellules Souches Et Radiations, iRCM/IBFJ, F-92265, Fontenay-aux-Roses Cedex, France.
Chloé BrizaisAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/LRTOX, F-92262, Fontenay-aux-Roses Cedex, France.
Léo MacéAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/LRTOX, F-92262, Fontenay-aux-Roses Cedex, France.
Christelle ElieAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/LRTOX, F-92262, Fontenay-aux-Roses Cedex, France.
Nicolas Cailler GruetAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/LRTOX, F-92262, Fontenay-aux-Roses Cedex, France.
Théo TeuladeAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/LRTOX, F-92262, Fontenay-aux-Roses Cedex, France.
Chloé HavetAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/LRTOX, F-92262, Fontenay-aux-Roses Cedex, France.
Frédéric VoyerAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/GSEA, F-92262, Fontenay-aux-Roses Cedex, France.
Imène GaraliAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/LRTOX, F-92262, Fontenay-aux-Roses Cedex, France.
Céline GloaguenAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/LRTOX, F-92262, Fontenay-aux-Roses Cedex, France.
François GensdarmesAutorité de Sûreté Nucléaire et de Radioprotection, PSN-RES/SCA/LPMA, F-91400, Saclay, France.
Dmitry KlokovAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/LRTOX, F-92262, Fontenay-aux-Roses Cedex, France.
Chrystelle IbanezAutorité de Sûreté Nucléaire et de Radioprotection, PSE-SANTE/SESANE/LRTOX, F-92262, Fontenay-aux-Roses Cedex, France. chrystelle.ibanez@asnr.fr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Throughout their lives, individuals are exposed to various pollutants, potentially including co-exposure to radiological and chemical stressors. Yet, existing literature about these combinations is scarce. We selected tungsten and ionizing radiations. Tungsten is an emerging contaminant present as aerosolized particles in several scenarios, potentially concurrently with low-dose irradiation, causing a co-exposure. The cerebral toxicity of this co-exposure was studied after 24 h and 28 days in the frontal cortex and olfactory bulb of male Sprague-Dawley rats exposed to gamma irradiation (50 mGy) and/or inhalation of tungsten particles aerosol (80 mg.m

Indexed as

Gamma RaysInhalation ExposureTungstenAnimalsFrontal LobeMaleMicrogliaOlfactory BulbOxidative StressRatsRats, Sprague-DawleyTissue DistributionTungstenCo-exposureGamma-radiationInhalationLow dosesNeurotoxicityTungsten aerosol

Identifiers

PMID40419610
PMCPMC12106847

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.