Evidence map›Paper›PMID 40419540›Full record

ArticleScientific reports2025

Growth inhibition of Saccharomyces cerevisiae by SUMO-specific nanobodies.

Pavana Suresh, Sun Zhen-Yu Jim, Ishani Sahay, Allison Y Tang, Charlotte Wijne, Jin Gan, Novalia Pishesha, Jose L Avalos, Hidde Ploegh

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Pavana SureshProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. pavana.suresh@childrens.harvard.edu.
Sun Zhen-Yu JimDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Ishani SahayProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Allison Y TangDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.
Charlotte WijneProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Jin GanProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Novalia PisheshaDivision of Immunology, Boston Children's Hospital, Boston, MA, USA.
Jose L AvalosDepartment of Chemical and Biological Engineering, Princeton University, Princeton, NJ, USA.
Hidde PloeghProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. hidde.ploegh@childrens.harvard.edu.

Funding

Imposing order on the family of ubiquitin-conjugating (E2) enzymes through intracellular perturbation with nanobodiesDP1AI150593 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI PLOEGH, HIDDE L. · 2019 to 2023
$7.1M
Drosophila models of human mitochondrial diseasesR24OD035556 · OD · HARVARD MEDICAL SCHOOL · PI NORBERT PERRIMON · 2023 to 2026
$3.3M
UCSD PRIDE Faculty Development Program in Cardiovascular SciencesR25HL145817 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Robert Scott Ross, Joann Trejo · 2019 to 2026
$3.3M
NHLBI NIH HHS R25 HL145817NIAID NIH HHS DP1 AI150593NIH HHS 5DP1AI150593-05NIH HHS R24 OD035556
6 · The paper itself

Abstract

Four nanobodies (VHH1-4

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSingle-Domain AntibodiesSmall Ubiquitin-Related Modifier ProteinsBinding SitesCysteine EndopeptidasesProtein BindingSUMO-1 ProteinSumoylationCysteine EndopeptidasesSaccharomyces cerevisiae ProteinsSingle-Domain AntibodiesSmall Ubiquitin-Related Modifier ProteinsSMT3 protein, S cerevisiaeSUMO-1 ProteinUlp1 protease

Identifiers

PMID40419540
PMCPMC12106817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.