Evidence map›Paper›PMID 40419526›Full record

ArticleScientific reports2025

Immune, metabolic, anatomical, and functional features of people after successful tuberculosis treatment: an exploratory analysis.

Tariq Webber, Candice Macdonald, Michele Tameris, Nicolette Tredoux, Anandi Bierman, Andrea Gutschmidt, Susanne Tönsing, Andriëtte Hiemstra, Firdows Noor, Candice Snyders and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tariq Webber *South African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Candice Macdonald *South African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Michele TamerisSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Nicolette TredouxSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Anandi BiermanSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Andrea GutschmidtSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Susanne TönsingSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Andriëtte HiemstraSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Firdows NoorSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Candice SnydersSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Tracy RichardsonSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Bernadine FransmanSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Brian AllwoodDivision of Pulmonology, Department of Medicine, Stellenbosch University and Tygerberg Hospital, Cape Town, South Africa.
Mark HatherillSouth African Tuberculosis Vaccine Initiative, Institute of Infectious Disease and Molecular Medicine, Department of Pathology, University of Cape Town, Cape Town, South Africa.
Leanie KleynhansSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
André G LoxtonSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Gerhard WalzlSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Novel ChegouSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Nelita du PlessisSouth African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Jane A Shaw *South African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
Stephanus T Malherbe *South African Medical Research Council Centre for Tuberculosis Research, Biomedical Research Institute, Division of Immunology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. malherbe@sun.ac.za.

Funding

U.S. Civilian Research & Development Foundation (CRDF Global) G-202212-69613)
6 · The paper itself

Abstract

We explored the underlying mechanisms that may drive post-tuberculosis (TB) lung disease, a multifactorial, heterogenous, and prevalent disease. Extensive clinical phenotyping through fluorine-18 Fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT) scans, pulmonary function testing, and symptom and quality of life questionnaires, was performed on a cohort of 48 adults who completed TB treatment within 6 months prior. Immunological characteristics of paired blood- and bronchoalveolar lavage fluid (BALF)-derived immune cells were assessed by multiplex bead-based immunoassay, ELISA and flow cytometry. There was agreement between measures of inflammation on PET, the severity of anatomical abnormalities on CT, and pulmonary function testing. However, of these, only PET was associated with exercise tolerance and symptom scores. Measures of radiologic extent (total glycolytic activity and SUVmax on PET, and segments involved on CT) also correlated with proteins detected in blood that implicate type 1 (IFN-γ, TNFα, IL-12) and type 2 (IL-4, IL-33) responses, ongoing remodelling of lung tissue (MMPs), airways and vasculature (VEGF), as well as subsets of activated CD8

Indexed as

TuberculosisTuberculosis, PulmonaryAdultAgedBronchoalveolar Lavage FluidCytokinesFemaleFluorodeoxyglucose F18HumansLungMaleMiddle AgedPositron Emission Tomography Computed TomographyQuality of LifeRespiratory Function TestsCytokinesFluorodeoxyglucose F18FDG PET-CTFlow cytometryLuminexPost-Tuberculosis lung diseasePost-tuberculosis sequelaePTLDPulmonary tuberculosisSpirometry

Identifiers

PMID40419526
PMCPMC12106758

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.