Evidence map›Paper›PMID 40419469›Full record

ArticleCell death & disease2025

The TP53 Arg72Pro polymorphism predicts visual and neurodegenerative outcomes in retinal detachment.

Nadia Galindo-Cabello, Eva M Sobas-Abad, Rebeca Lapresa, Jesús Agulla, Ángeles Almeida, Antonio López, José Carlos Pastor, Salvador Pastor-Idoate, Ricardo Usategui-Martín

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nadia Galindo-CabelloUnit of Excellence Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain.
Eva M Sobas-AbadUnit of Excellence Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain.
Rebeca LapresaInstitute of Biomedical Research of Salamanca (IBSAL), University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.
Jesús AgullaInstitute of Biomedical Research of Salamanca (IBSAL), University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0001-9574-2549
Ángeles AlmeidaInstitute of Biomedical Research of Salamanca (IBSAL), University Hospital of Salamanca, University of Salamanca, CSIC, Salamanca, Spain.ORCID http://orcid.org/0000-0003-0485-8904
Antonio LópezUnit of Excellence Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain.
José Carlos PastorUnit of Excellence Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain.
Salvador Pastor-Idoate *Unit of Excellence Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain. salvador.pastor@uva.es.
Ricardo Usategui-Martín *Unit of Excellence Institute of Applied Ophthalmobiology (IOBA), University of Valladolid, Valladolid, Spain. ricardo.usategui@uva.es.ORCID http://orcid.org/0000-0001-7699-4388

Funding

Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) RD21/0002/0017 and RD24/0007/0008Ministry of Economy and Competitiveness | Instituto de Salud Carlos III (Institute of Health Carlos III) RD21/0002/0017, PI21/00727 and RD21/0006/0005
6 · The paper itself

Abstract

Retinal detachment (RD) separates the retina from the retinal epithelium, causing photoreceptor apoptosis and irreversible vision loss. Even with successful surgical reattachment, complete visual recovery is not guaranteed. The TP53 Arg72Pro polymorphism, implicated in apoptosis, has emerged as a potential predictor of RD outcomes. We investigated the impact of the Arg72Pro polymorphism on retinal neurodegeneration and functional recovery in patients. The underlying mechanisms were analyzed in a humanized TP53 Arg72Pro RD mouse model. In a cohort of 180 patients, carriers of the Pro allele exhibited decreased apoptotic gene expression and improved visual recovery. Complementary findings in mice revealed that the Pro variant preserved photoreceptor integrity and reduced apoptosis rates following RD. Our findings highlight the potential of this TP53 polymorphism as a biomarker for RD outcomes and a tool for tailoring therapies. This study underscores the importance of integrating genetic profiling into personalized medicine approaches to improve recovery of RD patients' visual outcomes.

Indexed as

Polymorphism, Single NucleotideRetinal DetachmentTumor Suppressor Protein p53AdultAgedAnimalsApoptosisDisease Models, AnimalFemaleHumansMaleMiceMiddle AgedTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID40419469
PMCPMC12106684

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.