Evidence map›Paper›PMID 40419467›Full record

ArticleNature communications2025

Endocannabinoids disinhibit the ventral tegmental nucleus of Gudden to dorsal premammillary nucleus pathway to enhance escape behavior following learned threat experience.

Ruikai Chai, Nawen Wang, Jinlu Nie, Zongyi Xu, Shuqian Zhang, Suixin Deng, Rongxin Wang, Mu Li, Xinyi Gao, Ruijie Geng and 10 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Ruikai Chai *Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China.
Nawen Wang *Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China.
Jinlu Nie *Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China.
Zongyi Xu *Department of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China.
Shuqian ZhangDepartment of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China.
Suixin DengDepartment of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China.
Rongxin WangDepartment of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China.
Mu LiDepartment of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China.
Xinyi GaoDepartment of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China.
Ruijie GengDepartment of Psychological Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Haibin LiDepartment of Psychological Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.ORCID http://orcid.org/0000-0002-4215-1283
Lei LiDepartment of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China.
Hebi WuDepartment of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China.
Zhiming LiDepartment of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China.
Tian-Lin ChengInstitute of Pediatrics, National Children's Medical Center, Children's Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China.ORCID http://orcid.org/0000-0003-0680-6710
Xiao-Hong XuInstitute for Brain Science, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China.
Yousheng ShuInstitute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 200032, China. yousheng@fudan.edu.cn.ORCID http://orcid.org/0000-0002-2834-2876
Huilin HongDepartment of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China. hlhong1001@hotmail.com.
Xiao HuangDepartment of Psychological Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China. huang.xiao@zs-hospital.sh.cn.ORCID http://orcid.org/0000-0002-6400-6570
Weisheng WangDepartment of Neurology, Jinshan Hospital, Institute for Translational Brain Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, 201508, China. weishengw@fudan.edu.cn.ORCID http://orcid.org/0000-0003-4546-3108

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Innate escape behaviors, while not requiring prior learning, are shaped by an animal's learned experiences, such as previous exposure. Here, we found that learned threat experience in mice enhances flight behaviors, which is linked to increased activation of cholecystokinin-expressing neurons in the dorsal premammillary nucleus (PMd

Indexed as

EndocannabinoidsEscape ReactionLearningVentral Tegmental AreaAnimalsBehavior, AnimalCholecystokininGABAergic NeuronsMaleMiceMice, Inbred C57BLParvalbuminsCholecystokininEndocannabinoidsParvalbumins

Identifiers

PMID40419467
PMCPMC12106801

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.