ArticleJournal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology2025
Clinicopathological Significance and Prognostic Value of the Caveolae Constitutive Proteins Dynamin-2 and Caveolin-1 in Oral Squamous Cell Carcinoma.
Article in Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Integrative Bulk and Single-Cell Transcriptomic Analysis Identifies a Hypoxia- and Lipid Metabolism-Related Prognostic Signature in Oral Squamous Cell Carcinoma: A Retrospective Study.International journal of molecular sciences · 2026Article
- Clinicopathological Significance and Prognostic Value of the Caveolae Constitutive Proteins Dynamin-2 and Caveolin-1 in Oral Squamous Cell Carcinoma.Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe investigated the clinicopathological significance of the expression of two caveolae component proteins, dynamin-2 (DNM2) and caveolin-1 (CAV1), in primary tumors of patients with oral squamous cell carcinoma (OSCC).
methodsImmunohistochemical staining for DNM2 and CAV1 was performed on resected primary tumor specimens from 80 OSCC patients, and the individual expressions and combined expression status of these proteins were analyzed in relation to clinicopathological factors and prognosis.
resultsWe observed that the DNM2 expression was significantly correlated with the OSCC T-classification and the stage, while CAV1 expression was significantly correlated with the mode of invasion and recurrence. Moreover, the combined DNM2/CAV1 expression status was significantly correlated with the T-classification, stage, cell differentiation, and recurrence. In terms of overall survival, the CAV1-positive patients had a significantly poorer prognosis compared to the CAV1-negative patients, and the patients who expressed neither DNM2 nor CAV1 had a significantly better prognosis than those expressing either or both proteins.
conclusionThese results suggest that in OSCC, the expression of DNM2 is involved in tumor growth and the expression of CAV1 is involved in tumor invasion, and DNM2 and/or CAV1 expression affects the progression and prognosis of OSCC. The expressions of DNM2 and CAV1 may therefore be useful markers for OSCC progression and prognosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.