Evidence map›Paper›PMID 40419241›Full record

ArticleEndoscopy2025

Assessing the accuracy of magnetic resonance imaging in identifying early rectal cancers suitable for endoscopic intermuscular dissection.

Lisa van der Schee, Rachel Carten, Sander C Albers, Janneke van den Bergh, Manon N G J A Braat, Arnold C Goede, Sabrine Kol, Miangela M Lacle, Banafsche Mearadji, Shira I Moos and 12 more

Abstract read
In one paragraph

Article in Endoscopy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Lisa van der Schee *Department of Gastroenterology and Hepatology, University Medical Centre Utrecht, Utrecht, Netherlands.ORCID 0000-0002-1296-4574
Rachel Carten *Department of Colorectal Surgery, Buckinghamshire Healthcare NHS Trust, Aylesbury, United Kingdom of Great Britain and Northern Ireland.
Sander C AlbersDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Janneke van den BerghDepartment of Radiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Manon N G J A BraatDepartment of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.
Arnold C GoedeDepartment of Colorectal Surgery, Buckinghamshire Healthcare NHS Trust, Aylesbury, United Kingdom of Great Britain and Northern Ireland.
Sabrine KolDepartment of Radiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Miangela M LacleDepartment of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.
Banafsche MearadjiDepartment of Radiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Shira I MoosDepartment of Radiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Irene M NotaDepartment of Radiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Nicky H G M PetersDepartment of Radiology, Maastricht University Medical Center, Maastricht, Netherlands.
Jip F PrinceDepartment of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.
Jorik J ReimerinkDepartment of Radiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Arantza Fariña SarasquetaDepartment of Pathology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Jeanette van VoorenDepartment of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.
Jan Hein T M van WaesbergheDepartment of Radiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Barbara A J BastiaansenDepartment of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Frank P VleggaarDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, Netherlands.
Leon M G MoonsDepartment of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, Netherlands.
Karin HorsthuisDepartment of Radiology, Amsterdam University Medical Centers, Amsterdam, Netherlands.
Gina BrownDepartment of Radiology, Imperial College London, London, United Kingdom of Great Britain and Northern Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Selection of rectal cancers suitable for endoscopic intermuscular dissection (EID) is challenging. We aimed to evaluate whether identification of ≥1 mm of preserved muscularis propria on magnetic resonance imaging (MRI), using a systematic reporting tool (mrSRT), can identify rectal cancers suitable for EID. Methods: An expert radiologist trained 12 study radiologists in the use of the mrSRT. The radiologists then assessed a retrospective series of MRIs from 269 consecutive patients with suspected deep submucosal invasive rectal cancer. The primary objective was to determine the diagnostic accuracy of ≥1 mm of preserved muscularis propria on MRI for selecting cases that can be resected with clear margins using EID (invasion limited to the circular muscularis propria [≤pT2circ]). Diagnostic accuracy was calculated for the expert radiologist, study radiologists, and a consensus diagnosis. Results: After applying the inclusion and exclusion criteria, 244 patient scans were included in the analysis. Histological classification confirmed 18 lesions (7.4%) were noninvasive, 109 (44.7%) were pT1, 56 (23.0%) were pT2circ, 21 (8.6%) were pT2long, 39 (16.0%) were pT3, and 1 (0.4%) was pT4. The overall diagnostic accuracy of ≥1 mm of preserved muscularis propria as a criterion for selection was 80.7% (95%CI 75.2–85.5) for the expert radiologist, 77.5% (95%CI 71.7–82.5) for the trained study radiologists, and 81.6% (95%CI 76.1–86.2) for a consensus diagnosis. Conclusion: Use of mrSRT to identify ≥1 mm of preserved muscularis propria on MRI allowed radiologists to assist in appropriate case selection for EID.

Indexed as

Endoscopic Mucosal ResectionMagnetic Resonance ImagingRectal NeoplasmsAdultAgedAged, 80 and overFemaleHumansIntestinal MucosaMaleMargins of ExcisionMiddle AgedNeoplasm InvasivenessRetrospective Studies

Identifiers

PMID40419241
PMCPMC12668270

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.