Evidence map›Paper›PMID 40418987›Full record

ArticleThe American journal of clinical nutrition2025

Ultraprocessed food intake and risk of ovarian and endometrial cancer in the NIH-AARP cohort: a prospective cohort analysis.

Caitlin P O'Connell, Hyokyoung G Hong, Leila Abar, Neha Khandpur, Eurídice Martínez Steele, Linda M Liao, Rashmi Sinha, Britton Trabert, Erikka Loftfield

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Article in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Caitlin P O'ConnellMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, United States.
Hyokyoung G HongBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, United States.
Leila AbarMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, United States.
Neha KhandpurDivision of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands.
Eurídice Martínez SteeleNUPENS, School of Public Health, University of São Paulo, São Paulo, Brazil.
Linda M LiaoMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, United States.
Rashmi SinhaMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, United States.
Britton TrabertDepartment of Obstetrics and Gynecology, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, United States; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, United States.
Erikka LoftfieldMetabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, United States. Electronic address: erikka.loftfield@nih.gov.

Funding

Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

backgroundUltraprocessed food (UPF) accounts for more than half of caloric intake by the United States population. UPF intake has been linked to weight gain and obesity, a known risk factor for cancer, including endometrial cancer.

objectivesThe objectives of this study were to evaluate the prospective association of UPF intake with ovarian and endometrial cancer risk.

methodsParticipants in the NIH-AARP Diet and Health Study reported baseline diet using a food frequency questionnaire (FFQ). We disaggregated FFQ items to assign Nova classification and created quintiles of energy-adjusted UPF intake (grams/day). We used Cox proportional hazards models, adjusted for potential confounding factors, to estimate hazard ratios (HRs) and 95% confidence intervals (CI) for epithelial ovarian and endometrial cancer incidence, overall and by histotype.

resultsAmong 129,870 female participants, without a history of oophorectomy or cancer, 1234 epithelial ovarian cancer cases were diagnosed during >20 y of follow-up. UPF intake was not associated with ovarian cancer risk (quintile 5 compared with quintile 1: HR: 0.92; 95% CI: 0.77, 1.11), overall or by histotype. Among 107,592 female participants, without a history of hysterectomy or cancer, 2249 endometrial cancer cases were diagnosed. Participants in the highest quintile of UPF intake tended to have higher BMI (in kg/m

conclusionsIn this cohort of United States females who were at risk of developing endometrial or ovarian cancer, we found evidence of a positive association between UPF intake and endometrial, but not ovarian cancer. The positive association with endometrial cancer was not independent of BMI.

Indexed as

DietEndometrial NeoplasmsFast FoodsFood HandlingOvarian NeoplasmsAgedCohort StudiesEnergy IntakeFemaleHumansIncidenceMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsUnited Statescancerendometrial cancerepidemiologyNovaovarian cancerultraprocessed food

Identifiers

PMID40418987
PMCPMC12405777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.