Evidence map›Paper›PMID 40418643›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2025

Gly-βMCA modulates bile acid metabolism to reduce hepatobiliary injury in

Mohammad Nazmul Hasan, Huaiwen Wang, Wenyi Luo, Yanhong Du, Tiangang Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mohammad Nazmul HasanHarold Hamm Diabetes Center, Department of Biochemistry and Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.ORCID 0000-0003-4196-0406
Huaiwen WangLaboratory for Molecular Biology and Cytometry Research, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
Wenyi LuoDepartment of Pathology, Yale University, New Haven, Connecticut, United States.
Yanhong DuHarold Hamm Diabetes Center, Department of Biochemistry and Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.
Tiangang LiHarold Hamm Diabetes Center, Department of Biochemistry and Physiology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States.ORCID 0000-0001-8568-0129

Funding

Regulation of Bile Acid Metabolism and Signaling in Metabolic DiseasesR01DK117965 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Tiangang Li · 2019 to 2026
$2.7M
Sulfur Amino Acid Metabolism and Regulation of Hepatic Metabolic FlexibilityR01DK131064 · NIDDK · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LI, TIANGANG · 2022 to 2025
$1.6M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1R01 DK117965-01A1HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 1R01DK131064-01NIDDK NIH HHS R01 DK117965NIDDK NIH HHS R01 DK131064
6 · The paper itself

Abstract

Cholestasis results from impaired bile flow that causes accumulation of hepatic bile acid and injury. Alleviating bile acid hepatobiliary toxicity is a major therapeutic goal in cholestasis. Our recent study revealed a potent anticholestasis effect of glycine-conjugated β-muricholic acid (Gly-βMCA) in

Indexed as

ATP Binding Cassette Transporter, Subfamily BBile Acids and SaltsCholestasisCholic AcidsGlycineLiverAnimalsCytochrome P-450 Enzyme SystemCytochrome P450 Family 2Disease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMice, KnockoutATP Binding Cassette Transporter, Subfamily BBile Acids and SaltsCholic Acidscytochrome P-450 2C70, mouseCytochrome P-450 Enzyme SystemCytochrome P450 Family 2Glycinemuricholic acidbile acidcholestasisFXRliver injurytherapy

Identifiers

PMID40418643
PMCPMC12178242

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.